mRNA based therapeutics have evolved emerged as a promising platform in modern medicine because they facilitate provisional production of specific protein within cells. Their applications extend beyond infectious disease vaccines to cancer immunotherapy, protein replacement, gene editing, regenerative medicine, and tre...
Ashok Kumar P, Bhargavi S, Bhavana L et al.· Zenodo (CERN European Organi...· 0 citations
This work proposes an executable framework for individualized atherosclerosis therapy that organizes clinical decision‐making around three axes: actionable endotype identification, selection of a matched therapeutic modality, and evaluation of delivery feasibility.
Yun-Dong Peng, Rui Li, Huan Li et al.· Medicine Bulletin· 0 citations
THE EL-RAKHAWI CREED presents a groundbreaking Islamic-scientific exploration of the human genome as a divine sign (ayah) of Allah's infinite wisdom. Grounded in the absolute conviction that Allah alone is the Creator (Al-Khaliq) and Islam is His final religion, this work transcends conventional molecular biology to re...
mohamed kamal arafa el-rakhawi· Zenodo (CERN European Organi...· 0 citations
Soil salinization is a major threat to global food security and sustainable agriculture, soil salinization affects approximately 8.31 × 108 hm2 of soil resources globally. The remediation and productive use of saline-alkali land have therefore become urgent global challenges. This review summarises the classification a...
Wen-Jing Zhang, Zhen Wang, Xin-Yu Du et al.· Plant, Cell and Environment· 0 citations
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Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by repetitive behavior and impaired social interactions. Recent reports from human postmortem brain samples of ASD show transcriptome-wide dysregulations, including changes in differential gene expression and alternative splicing. An importan...
Tourmaline v2.1.0 This release adds two new taxonomy features — the REVAMP classify method by Sean McAllister and optional Krona plots — and has a major overhaul of the documentation. Existing configuration files continue to work unchanged. No parameters were renamed or removed. Still requires QIIME 2 2024.10 in an env...
Luke Thompson, Katherine Silliman, Luke Thompson et al.· Zenodo (CERN European Organi...· 0 citations
A roadmap for developing crops with low metal accumulation and high stress tolerance through precision breeding and gene editing is provided, to provide a roadmap for developing crops with low metal accumulation and high stress tolerance through precision breeding and gene editing.
Liu-Liu Wu, Li-Fan Cao, Jun-Yan Sun et al.· Plant, Cell and Environment· 0 citations
Two novel knock-in mouse lines using CRISPR-Cas9-mediated genome editing provide faithful tools for investigating the cellular and molecular mechanisms regulating dentinogenesis and osteocyte biology, as well as for studying dental and alveolar bone tissues, with potential applications in craniofacial biology.
T.-H. Wang, M. Yang, Y. Liu et al.· Journal of dentistry researc...· 0 citations
Genome engineering via CRISPR/Cas9 has been widely applied in biological research and developing gene therapies. However, genome editing flexibility is strongly constrained by the position and quality of guide RNAs relative to the intended edit: desired edit sites are frequently positioned far from efficient protospace...
Chenfu Zhao, Yan Hong Cao, Kirill A. Martemyanov· bioRxiv (Cold Spring Harbor...· 0 citations
Clinically, PBDs are encompassed within the Zellweger spectrum disorders (ZSDs) and are encompassed within the Zellweger spectrum disorders (ZSDs) respectively.
Yong Hwan Kim, Doo Sin Jo, Ae-kyeong Kim et al.· Signal Transduction and Targ...· 0 citations
Genetic engineering of the myostatin gene in dairy cattle represents a promising approach for sex-specific beef performance enhancement. A possible genetic strategy to enhance beef traits in male dairy calves uses the introduction of a myostatin knockout on the Y chromosome. Using CRISPR/Cas9, this sex-specific edit wo...
Fernando Mata, Joaquim Cerqueira, Gustavo Paixão et al.· 0 citations
Editorial on the Research TopicTrends and perspectives for the use of crop wild relatives in crop breeding, volume II Crop wild relatives (CWRs) are crucial assets for agrobiodiversity, sustainable agriculture, and food security, offering vital genetic traits such as pest resistance, resource efficiency, and extreme we...
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
