CD4+ T cells orchestrate adaptive immunity and strategies that enable their genetic reprogramming hold promise for treating cancer, immune dysregulation and infectious diseases such as HIV. However, current T cell engineering approaches rely heavily on ex vivo manipulation, which is labor-intensive, costly, and can alt...
Maaike De Cock, Elianne Burg, Sarah Gerlo et al.· Advanced Healthcare Material...· 0 citations
Abstract Cancer, neurologic diseases, cardiovascular disease, metabolic disorders, immune disorders, and some inherited diseases are examples of epigenetic diseases. Traditional epigenetic drugs are non-specific and may be toxic at higher concentrations, may be unstable in transcription, and may have off-target effects...
Preprint — not yet peer reviewed. This pilot computational study evaluates a TCGA gene-expression cancer classifier across six cancer types: BRCA, COAD, READ, LUAD, LUSC, and OV. The analysis focuses on patient-grouped cross-validation, training-only preprocessing, class-specific performance, tissue-source-site confoun...
Hitesh Sharma· Zenodo (CERN European Organi...· 0 citations
A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...
Lucian-Razvan Popovici· Zenodo (CERN European Organi...· 0 citations
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A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...
Lucian-Razvan Popovici· Zenodo (CERN European Organi...· 0 citations
This comprehensive foundational module analyzes the systems architecture and developmental mechanics of emerging technologies across the modern STEM curriculum. Developed by Prep4Uni.Online, this resource serves as an analytical bridge connecting laboratory-stage scientific discovery to scalable industrial engineering...
Prep4Uni.Online· Zenodo (CERN European Organi...· 0 citations
A novel theoretical concept in bio-hybrid robotics and tissue engineering: a macroscopic biological muscle actuator engineered from the stem cells of the Oriental Hornet (Vespa orientalis). The system utilizes CRISPR-Cas9 genome editing to multiply the Alcohol Dehydrogenase (NADP+) gene for absolute alcohol immunity, c...
Lucian-Razvan Popovici· Zenodo (CERN European Organi...· 0 citations
1. What is already done, and what this document covers I state this first, because the value of a preregistration written after related work depends on being exact about what was already seen. Three analyses are already complete and are exploratory. None of them was preregistered, and none of them is covered by this do...
Abstract Cancer, neurologic diseases, cardiovascular disease, metabolic disorders, immune disorders, and some inherited diseases are examples of epigenetic diseases. Traditional epigenetic drugs are non-specific and may be toxic at higher concentrations, may be unstable in transcription, and may have off-target effects...
Preprint — not yet peer reviewed. This pilot computational study evaluates a TCGA gene-expression cancer classifier across six cancer types: BRCA, COAD, READ, LUAD, LUSC, and OV. The analysis focuses on patient-grouped cross-validation, training-only preprocessing, class-specific performance, tissue-source-site confoun...
Hitesh Sharma· Zenodo (CERN European Organi...· 0 citations
How advances in large DNA assembly, synthetic biology, and genome-wide validation are making chromosome-scale genome engineering an increasingly tractable experimental framework for understanding, building, and repairing genomes is discussed, while outlining the analytical requirements and current technical barriers th...
Miriam Saponaro, Pierre Murat, Francesca Agostini et al.· Trends in Genetics· 0 citations
A complete, gap-free genome of Medicago lupulina, a tough, high-protein forage legume, and a gene-editing tool for this species, which was used to alter its leaf shape, provide key resources for improving alfalfa and breeding better forage crops for high-altitude environments.
Qing Yuan, Cheng Li, Guang-Yan Wang et al.· Journal of Integrative Plant...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
