Overall, CRISPR-based technologies show considerable potential to support precision oncology in prostate cancer by enabling molecularly informed therapeutic strategies and addressing treatment resistance, although challenges related to delivery, off-target effects, tumor heterogeneity, immunogenicity, and clinical tran...
Vaibhavkumar Patel, Pratichi Singh, S. Dutta et al.· Critical reviews in oncology...· 0 citations
This study establishes the feasibility of dCasRx-mediated programmable RNA base editing in plant cells and lays a foundation for further optimization of editing efficiency and stable in planta editing performance.
Xue-Ming Ruan, Zi-Yan Zhang, Xiang-Yu Xiong et al.· Biochemical and Biophysical...· 0 citations
The adaption of the continuous directed evolution (CDE) along with base editor (BE) gene editing strategy to discover TEM-1 mutants is reported here and highlights the application of gene editing methods to provide insight into the molecular basis of antibiotic resistance.
Hong Wang, Jia-Mei Wang, Ding-Jue Zhang et al.· Biotechnology Letters· 0 citations
Aims: This study develops a dynamic explanation for the gap between task-level artificial intelligence productivity and durable enterprise value. It introduces verification debt, the accumulated stock of unverified assumptions, weak review, concealed dependencies, deferred validation, and capability loss.
Study Design:...
Kwan-Hong Tan· Journal of global economics,...· 4 citations
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CRISPR-Cas12a represents an efficient tool for genome editing in addition to the extensively investigated CRISPR-Cas9. However, development of efficient nonviral delivery system for CRISPR-Cas12a remains challenging. Here, we demonstrate a DNA nanoclew (NC)-based carrier for delivery of Cas12a/CRISPR RNA (crRNA) ribonu...
Xingwu Zhou, Jinqiang Wang, Quanyin Hu et al.· UNC Libraries· 0 citations
NEW AUDIO INTERVIEW - Camilo Fernández Bravo, MD/PhD/FACC, Editor in Chief, on the Future of Clinical and Translational Cardiology** --- **HOST:** Welcome to our New Audio Interview series. Today we have a true leader in modern cardiology. Dr. Camilo Fernández Bravo, MD, PhD, FACC, Editor in Chief of the Journal of Cli...
Camilo Fernández Bravo· Zenodo (CERN European Organi...· 0 citations
India regulates two of the twenty-first century's most ethically fraught technologies, consumer and clinical neurotechnology, and human germline gene editing, almost entirely through non-binding administrative guidance rather than enforceable statute. This paper examines that pattern through two case studies: the treat...
Sachin Chauhan· Zenodo (CERN European Organi...· 0 citations
# M-SCAN RNA-to-pFBA Tutorial M-SCAN builds Human-GEM reaction-capacity constraints from RNA expression, optional deleterious mutation attenuation, predicted kcat values, and medium constraints, then runs pFBA. The bundled three-sample CCLE example reproduces the Figure 2 mini-reference outputs and is also a template f...
Songwon Lim, Jae Woo Baek, Y David Seo et al.· WorkflowHub· 0 citations
Sense‒antisense overlapping gene pairs are widespread in plant genomes and constitute an important layer of gene regulation. However, only a few natural antisense transcripts (NATs) have been functionally characterized, primarily as regulators of their sense counterparts via small RNAs or long noncoding RNAs. Here, we...
Shu-Min Li, Fu-Jie Chang, Xiao-Chun Wang et al.· Rice· 0 citations
Knee osteoarthritis (OA) is a disabling whole-joint disease involving synovial inflammation and myeloid-cell activation. A-to-I RNA editing can regulate endogenous dsRNA sensing and protein recoding, but its dynamics across synovial monocyte-macrophage cell states remain unclear. We analyzed 12 RNA-seq libraries from s...
Yingming Chu, Boyang Yi, Xinyue Cao et al.· Human Genomics· 0 citations
The applicable boundaries and complementary relationship between CRISPRoff and CRISPRon are clarified and a theoretical direction for tool selection and collaborative strategies is provided, such as in vivo collaborative application and delivery efficiency.
Yi-Zhi Wang· Explore Medical Science and...· 0 citations
India regulates two of the twenty-first century's most ethically fraught technologies, consumer and clinical neurotechnology, and human germline gene editing, almost entirely through non-binding administrative guidance rather than enforceable statute. This paper examines that pattern through two case studies: the treat...
Sachin Chauhan· Zenodo (CERN European Organi...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
