Haplotype structure of a candidate gene provides crop geneticists with a wealth of information, including the interpretation of GWAS peaks, the identification of suitable parents for cross-breeding to achieve allelic diversity, and the placement of a diagnostic marker. Resequencing efforts, such as the 3,010 Rice Genom...
Hyun-oh Lee, Mina Kim, Yeeun Jun et al.· BMC Bioinformatics· 0 citations
FigureLab is a single-file, browser-based application for assembling publication-quality scientific figures from image data (microscopy, western blots, histology, gels, and clinical or specimen photographs). It runs entirely client-side with no installation, server, or internet connection required, so no image data eve...
Michael Baffour Awuah· Zenodo (CERN European Organi...· 0 citations
This review examines the literature over the past decades on mitochondrial disease treatments, including traditional Cocktail therapy, target therapy, multidisciplinary management, gene therapy, mtDNA base editing, and mitochondrial replacement therapy.
Chao-Ping Hu, Xiao-Lei Wang, Fang-Hao Fang et al.· Journal of Translational Gen...· 0 citations
A novel role for Ctbp1 is uncovered in craniofacial development and the complex genetic and molecular signaling in the pathogenesis of craniofacial malformations is highlighted.
P. Iyyanar, Beulah Solivio, K. Weaver et al.· bioRxiv· 0 citations
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A first representative population survey in the United Kingdom of attitudes and views towards xenotransplantation (XTx), highlighting the importance of demonstrating to the public that XTx can be provided safely while ensuring high standards of animal welfare.
M. Al-Haboubi, P. Boadu, A. Pacho et al.· Transplant International· 0 citations
Coordinated crosstalk among Wnt, Notch, EGF/ErbB, and BMP pathways forms a dynamic regulatory network that dictates ISC fate, providing strategic targets for regenerative medicine and intestinal disease interventions.
Ziasmin Khatun, Shoaib Saikat, Shaila Haque· Current Biomedicine· 0 citations
Novel targeted drugs are currently available for all patients with intrahepatic cholangiocarcinoma (ICC). The goal of this study was to investigate the association between A Disintegrin and Metalloproteinase8/17 (ADAM8/17) and ICC, and to determine whether ADAM8/17 could be a novel target for ICC treatment. The express...
Kaisi Yang, Lei Han, Xiaoxuan Song et al.· Journal of Cancer Research a...· 0 citations
Idiopathic normal pressure hydrocephalus (iNPH) is characterized by gait disturbance, cognitive impairment, and urinary incontinence. Emerging evidence suggests that ependymal ciliary dysfunction contributes to the pathophysiology of chronic hydrocephalus, including iNPH. We previously identified DNAH14 as a causative...
Kaito Kawamura, Madoka Nakajima, Masakazu Miyajima et al.· Fluids and Barriers of the C...· 0 citations
### Genetic Engineering — Research Project This research project focuses on the principles, technologies, applications, and emerging developments of genetic engineering and modern molecular biotechnology. The project brings together scholarly work covering genetics, genomics, molecular biology, recombinant DNA technolo...
Zeeshan Qaiser· Open Science Framework· 0 citations
How Life Is Executed presents an integrated framework for understanding life as a process in which information is executed, material structures are produced, boundaries are maintained, and the capacity for execution is reconstructed across generations. The book applies WRRA (Wonsik Reality-Renderer Architecture)—a fram...
Wonsik Choi, Jeongin Choi· Zenodo (CERN European Organi...· 0 citations
It is suggested that even modest levels of base editing-mediated exon skipping may ameliorate the DMD cardiac phenotype toward a BMD-like state, supporting the translational potential of this dual rAAV base editing approach for DMD cardiomyopathy.
Ina Luksch, Christine M. Poch, Aylin Mayer et al.· Human Gene Therapy· 0 citations
The generation of gene-edited ovine cells through non-homologous end-joining (NHEJ) and homology-directed repair (HDR), followed by the production of cloned embryos carrying the mutations of interest is described.
Carson Stoker, Yasmin Mustafa, Ying Liu et al.· Journal of Visualized Experi...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
