Findings establish ADAR enzymes as candidates tissue biomarkers of TAA severity and ADAR1 as the principal driver of epitranscriptomic dysregulation in MFS aortopathy.
Calogera Pisano, A. Colopi, Domenico Alessandro Silvestris et al.· International Journal of Mol...· 0 citations
CRISPR-based epigenome editing represents a programmable strategy to precisely modulate gene expression, holding promise for therapeutic applications. However, the large size of dCas proteins substantially impedes delivery using adeno-associated virus (AAV) vectors. Here, through iterative bioinformatics analysis, stru...
Tao Yu, Meng Ji, Donglin Yu et al.· Nature Structural & Molecula...· 0 citations
This strategy provides an efficient workflow for gene knockout that is rapidly confirmed through PCR amplification of mRNA derived from the targeted gene loci that is rapidly confirmed through PCR amplification of mRNA derived from the targeted gene loci.
Michael Tobin, Jie Dai, Li-Chuan Chan et al.· STAR Protocols· 0 citations
Across global energy systems, the adoption of drop-in fuels offers a practical pathway to decarbonization while preserving the value of existing petroleum infrastructure. Their molecular similarity to fossil fuels eliminates the compatibility issues that hindered earlier biofuels such as ethanol and biodiesel. As a res...
Arul Kulandaivel, V. Prabhakaran, B. G. Sivakumar et al.· 0 citations
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Most genetic diversity stems from spontaneous mutations, that is, errors in DNA repair or replication. But for dozens of organisms across the tree of life, mutations at specific loci are not spontaneous but developmentally programmed: effectively, some organisms edit their own DNA sequences. This is perhaps most common...
Vincent C. T. Hanlon, Unnati Sonawala, Cian A. A. Raza et al.· PLoS ONE· 0 citations
Python-native pipeline: CRISPR detection, HMM searches, and ORF prediction now run in-process (diced, pyhmmer, pyrodigal-gv); database/models ship with the wheel/sdist. Native repeat search backend: bundled edit-distance search (myers-batch + edlib) as a drop-in for BLAST+ near cas operons. --repeat_search_backend defa...
Jakob Russel, Mario Rodríguez Mestre· Zenodo (CERN European Organi...· 0 citations
4th International Plant Genetics & Genomics Conference (IPGG 2026)The 4th International Plant Genetics & Genomics Conference (IPGG 2026) brings together researchers, scientists, breeders, and students from around the world to exchange recent advances in plant genetics, genomics, molecular breeding, and crop improvement...
4th International Plant Genetics & Genomics Conference (IPGG 2026)The 4th International Plant Genetics & Genomics Conference (IPGG 2026) brings together researchers, scientists, breeders, and students from around the world to exchange recent advances in plant genetics, genomics, molecular breeding, and crop improvement...
Heilongjiang and Jilin's early-maturing Geng / japonica (EMG) rice—grown at the world's northernmost latitude—delivers 17.3% of China's rice grain from only 16.0% of the national paddy area, yet every newly approved cultivar must combine early heading (EH) and blast resistance (BR). Transgressive photoperiod sensitivit...
Yuanbao Lei, Dechen Yang, Huanbin Shi et al.· Rice· 0 citations
How Life Is Executed presents an integrated framework for understanding life as a process in which information is executed, material structures are produced, boundaries are maintained, and the capacity for execution is reconstructed across generations. The book applies WRRA (Wonsik Reality-Renderer Architecture)—a fram...
Wonsik Choi, Jeongin Choi· Zenodo (CERN European Organi...· 0 citations
The studies reviewed suggest that biotechnology should not be treated as a replacement for habitat protection or ecological restoration, and its value lies mainly in extending the range of tools available to conservation practitioners.
Oluwaseyi Joseph Olukayode, Oghenerabome Okpro, S. West et al.· American Journal of Life Sci...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.