Through multidisciplinary treatment and continuous scientific progress, individualized precision medicine that integrates therapies targeting secondary pathogenic pathways with dystrophin-restoration techniques can finally convert this devastating illness into a tolerable chronic ailment.
Shahjad Ansari, M. Saifi, Sarfaraz Ahmed et al.· Current pharmaceutical desig...· 0 citations
It is argued that the most defensible therapeutic objective is not permanent genome editing or autonomous organ regeneration, but spatially confined, temporally limited, and reversible regulation of validated fibrotic or protective gene programs using CRISPRa, CRISPRi, or dCas9-based epigenome editors.
B. Taha, Ali J. Addie, A. Haider et al.· Journal of Photochemistry an...· 1 citation
This study defines effective multiplex target combinations for ultra-high oleic, low-saturated soybean by simultaneously targeting fatty acid desaturase 2 (FAD2) and fatty acyl-ACP thioesterase B (FATB) gene families using CRISPR/Cas9.
W. Kim, Yu-Ri Choi, H. Kim et al.· Plant Biotechnology Journal· 0 citations
For farmers and consumers to reap the benefits of gene-edited plants, guidelines for farming gene-edited plants must be implemented with careful thought.
N. De Storme· Nature· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
Content of image described in text. Summary Genetic management of threatened species to reduce extinction risk is sometimes considered controversial, with earlier surveys demonstrating that the general public are more cautious about genetic management than about some other conservation interventions including killing f...
K. Zander, P. Sunnucks, C. Hogg et al.· Bird conservation internatio...· 0 citations
Carbapenem-resistant Klebsiella pneumoniae (CRKP) has become a substantial public health threat worldwide. This trend is undoubtedly exacerbated by biofilm formation, which is closely related to bacterial virulence. Small RNAs (sRNAs) are post-transcriptional regulators of many biological processes in bacteria, includi...
Na Du, Min Yang, Yong-Shi Zhao et al.· Microorganisms· 0 citations
Highly efficient tissue culture and transformation systems are indispensable for micropropagation, the molecular studies of secondary metabolism, the biotechnological enhancement of bioactive compounds, and genome editing in plants. Solanum americanum is a diploid species with both vegetable and medicinal value, yet re...
This study uses giant unilamellar vesicles mimicking the endosomal membrane to directly visualize the interaction and membrane disruptions caused by two model LNPs constituted by two different ionizable lipids, establishing a cell-free platform for dissecting individual sub-steps of endosomal escape.
functional-standard-atlas: attenuation-corrected, territory-resolved benchmarking of variant effect predictors against saturation genome editing Software and frozen data underlying the manuscript "Measurement reliability bounds functional benchmarks and relocates where variant effect prediction fails" (N. Zhang). WHAT...
Ningyi Zhang· Zenodo (CERN European Organi...· 0 citations
The results reveal a unique human mechanism of disease and offer therapeutic insight for this inflammasomopathy and CRISPR editing of human CD34+ hematopoietic stem and progenitor cells (HSPCs) led to very efficient and persistent gene deletion in vivo.
Tian-Li Xiao, J. R. Brewer, Maximillian J. Carlino et al.· Journal of Clinical Investig...· 0 citations
It was concluded that these technologies surpass the biological efficiency thresholds necessary to halt retinal degeneration and are established not as universal solutions, but as complementary tools whose selection depends strictly on the genetic architecture of the pathology.
The study confirms the usefulness of the rpoC1 gene region for identifying A.hydridus and provides additional molecular data for species, which may support plant identification and biodiversity documentation of Amaranthus based products.
K. Abdulkareem, Precious Ayantayo, Shehu Tsoho et al.· FUDMA Journal of Sciences· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
