Renal fibrosis is the irreversible pathological core of chronic kidney disease (CKD). Current treatments can slow disease progression, but cannot cure it. Epigenetic regulatory mechanisms provide new perspectives for understanding and intervening in this process. This review summarizes the core epigenetic regulatory ne...
The year 2025 marked significant advances in autologous cellular therapy for melanoma and solid tumors, building on landmark regulatory approvals in 2024. Lifileucel, the first Food and Drug Administration‐approved tumor‐infiltrating lymphocyte (TIL) therapy for advanced melanoma, demonstrated durable efficacy in the 5...
Consumer acceptance of insulin produced via a gene-edited production system compared with insulin produced using conventional genetically modified microbial methods is examined to suggest that affordability plays a more influential role than perceived safety in shaping consumer acceptance of emerging biotechnology-base...
Nathan P. Kemper, B. McFadden· Agricultural and Resource Ec...· 0 citations
A CS•CBE integrative delivery and editing system via chitosan and cytosine base editor (CBE), which could successfully target and inhibit the phosphorylation of β-catenin, serves as a valuable research tool for targeted protein modulation, downstream target identification, and probe specific post-translational modifica...
Min Li, Qian Ban, Da-Hai Liu et al.· ACS Omega· 0 citations
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FigureLab is a single-file, browser-based application for assembling publication-quality scientific figures from image data (microscopy, western blots, histology, gels, and clinical or specimen photographs). It runs entirely client-side with no installation, server, or internet connection required, so no image data eve...
Michael Baffour Awuah· Zenodo (CERN European Organi...· 0 citations
This review evaluates oncolytic virotherapy, gene-editing technologies, engineered immune-cell therapies, nanotechnology-enabled delivery systems, and artificial intelligence-assisted precision oncology according to the PDAC barriers they are intended to address and the maturity of the supporting evidence.
Yang Li, Yu Li, Jia Fan et al.· Frontiers in Immunology· 0 citations
The plastid genomes of Salvia are structurally conservative but contain sufficient localized variation for marker development and species discrimination, and the expanded plastome phylogeny improves resolution of major evolutionary lineages within the genus.
Amorphophallus is an important genus within Araceae, possessing economic value and considerable ornamental diversity. However, accurate taxonomic identification using traditional methods remains challenging due to pronounced morphological plasticity and the temporal separation of leaf and flower emergence. To date, lar...
HIV has challenged humanity for decades, quietly establishing latent reservoirs that evade even the most potent antiretroviral therapies (ART). While ART transformed HIV from a fatal disease into a manageable condition, the virus’s hidden persistence continues to fuel the global epidemic. This review narrates the story...
Z. Safaei, K. Khalili· Journal of Neurovirology· 0 citations
This research paper explores the potential of CRISPR-based therapeutic approaches in the diagnosis, treatment, and management of lung cancer. It examines how CRISPR-Cas genome-editing technologies can be used to identify and modify cancer-associated genes, investigate molecular mechanisms of tumor development, and deve...
Genetic Engineering: Principles, Technologies, Genomics, Genome Editing and Translational ApplicationsThis book provides a comprehensive and contemporary overview of genetic engineering, covering its fundamental principles, molecular technologies, genomic applications, genome editing approaches, and emerging translatio...
Toxicodendron vernicifluum is an economically important lacquer-producing tree endemic to East Asia; propagation bottlenecks severely restrict elite clone industrialization. This review summarizes 20 years of the domestic and international literature on seed propagation, root cutting, stem cutting, grafting, and tissue...
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.