The CRISPR-Cas9-mediated deletion of endogenous retrovirus-derived cis-regulatory elements in human naive pluripotent stem cells enables direct functional interrogation of species-specific non-coding regulatory sequences and supports the study of transcriptional mechanisms involved in early human development.
Yun-Ying Huang, Merel Wentink, R. Fueyo· Journal of Visualized Experi...· 0 citations
Where genetic accessibility can be established, the integration of CRISPR technology with synthetic biology may enable more precise gene regulation and could support the development of next-generation engineered Bifidobacterium-based platforms.
Cancer remains a major global health challenge due to its genetic complexity, tumor heterogeneity, and the development of therapeutic resistance.Conventional treatment modalities, including surgery, chemotherapy, immunotherapy, and radiotherapy, often fail to completely eradicate malignant cells and may cause significa...
Mahmood S. Choudhery, Taqdees Arif, Ruhma Mahmood et al.· WArtificial Intelligence in...· 0 citations
BMAL1 is a core circadian transcription factor that also regulates stem cell fate, yet its role in human embryonic stem cell neurodifferentiation remains incompletely understood. Circadian disruption is associated with adverse neurodevelopmental outcomes, while N6 methyladenosine (m6A) RNA modification is a key regulat...
Bing Cai, Tianrui Wen, Boyan Wang et al.· Genome biology· 0 citations
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महा इम्यूनिटी सूत्र (MHA Immunity Sutra): वायरस के खिलाफ इंसानी शरीर का नया सुरक्षा कवचआविष्कारकर्ता (Inventor): बंटी कुमावतकल्पना कीजिए एक ऐसी दुनिया की जहाँ "महामारी" (Pandemic) शब्द का नामोनिशान ही मिट जाए। एक ऐसी दुनिया जहाँ कोई भी नया, पुराना या रूप बदलने वाला वायरस जैसे ही किसी इंसान के शरीर को छुए, वहीं पर बेअसर...
Banti Kumawat· Zenodo (CERN European Organi...· 0 citations
The Sk-3 selfish genetic element in Neurospora fungi is transmitted to offspring in a biased manner through spore killing. In crosses between an Sk-3 strain and a Spore killing-sensitive (Sk-S) strain, nearly all offspring that fail to inherit Sk-3 are killed. Although a mutation called rfk-2UV, which disrupts spore ki...
महा इम्यूनिटी सूत्र (MHA Immunity Sutra): वायरस के खिलाफ इंसानी शरीर का नया सुरक्षा कवचआविष्कारकर्ता (Inventor): बंटी कुमावतकल्पना कीजिए एक ऐसी दुनिया की जहाँ "महामारी" (Pandemic) शब्द का नामोनिशान ही मिट जाए। एक ऐसी दुनिया जहाँ कोई भी नया, पुराना या रूप बदलने वाला वायरस जैसे ही किसी इंसान के शरीर को छुए, वहीं पर बेअसर...
Banti Kumawat· Zenodo (CERN European Organi...· 0 citations
This research provides a comprehensive overview of genetic engineering and chimeric antigen receptor T-cell (CAR-T) therapy in the treatment of hematological malignancies. It examines the development of CAR-T cell therapies targeting clinically important antigens, particularly CD19 and B-cell maturation antigen (BCMA),...
This archive supports the manuscript "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (submission target: Critical Care, BMC; manuscript version v2.30, September 2026). Contents: (1) complete analysis code (R 4.6.1 / Pyt...
Huangwei Lin, Yuanshui Liu· Zenodo (CERN European Organi...· 0 citations
This review paper explores the potential of CRISPR-Cas9 gene-editing technology to enhance human performance across muscular, metabolic, and neurocognitive domains. It synthesizes the genetic mechanisms (such as ACTN3, MSTN, EPOR, and BDNF), clinical applications, safety risks, and ethical considerations surrounding hu...
OMAR MOHAMMAD OMAR MOHAMMAD ALKHAZALEH· Zenodo (CERN European Organi...· 0 citations
This research provides a comprehensive overview of genetic engineering and chimeric antigen receptor T-cell (CAR-T) therapy in the treatment of hematological malignancies. It examines the development of CAR-T cell therapies targeting clinically important antigens, particularly CD19 and B-cell maturation antigen (BCMA),...
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
