gene editing

Genetic Enhancement – CRISPR & Human Performance

This review paper explores the potential of CRISPR-Cas9 gene-editing technology to enhance human performance across muscular, metabolic, and neurocognitive domains. It synthesizes the genetic mechanisms (such as ACTN3, MSTN, EPOR, and BDNF), clinical applications, safety risks, and ethical considerations surrounding hu...

Mitoxyperilysis-ARDS: analysis code, six-layer gene signature, and frozen statistical outputs for "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (archive v5; manuscript v2.30)

This archive supports the manuscript "Mitoxyperilysis-consistent L4 de-protection in human sepsis-associated ARDS blood: a compartment- and etiology-bounded transcriptomic boundary map" (submission target: Critical Care, BMC; manuscript version v2.30, September 2026). Contents: (1) complete analysis code (R 4.6.1 / Pyt...

Long Non-Coding RNAs in Fish Reproduction: Emerging Regulators from Gonadal Fate to Fertility

Long non-coding RNAs (lncRNAs) have emerged as important regulators of gene expression acting through transcriptional, post-transcriptional, and epigenetic mechanisms. In teleosts, high-throughput sequencing has identified a growing number of lncRNAs associated with gonadal development and reproductive function, yet cu...

APOE 4/4 promotes dysfunctional and inflammatory phenotypes concomitant with impaired maturation of hiPSC-derived astrocytes

The results indicate that APOE 4/4 alters astrocyte morphological and molecular maturation while promoting inflammation, disturbing glutamate and Aβ handling under basal conditions and suggests that APOE ε4/ε4 genotype disrupts astrocyte development and key processes of cellular homeostasis early in Alzheimer’s disease...

Assessment of omics and genome editing approaches for addressing climate challenges: Enhancing stress tolerance in tea (Camellia sinensis (L.) O. Kuntze)

The role of omics and genome editing is underscores the role of omics and genome editing in advancing research to improve tea cultivation and support its resilience against 21st Century climate changes.

Harnessing plant susceptibility genes into strategies for enhanced disease resistance

Key translational challenges, including pleiotropy, genetic background effects, pathogen adaptation, transgene footprints and regulatory divergence, that must be addressed to harness S genes for durable and agronomically balanced crop resistance are highlighted.

EFFECTIVENESS OF TREATING GENETIC DISEASES BY GENE THERAPY

This article analyzes the effectiveness of gene therapy in treating genetic diseases, its main molecular mechanisms, and modern technologies. Key therapeutic approaches such as gene addition, gene function restoration, gene expression silencing, and targeted genome editing are covered. The potential of modern gene deli...

CRISPR/Cas9-Mediated Knockout of LXRα and LXRß in MCF-7 Breast Cancer Cells, Revealing Their Roles in Target Gene Regulation and Cell Proliferation

CRISPR/Cas9‐mediated gene editing and its application for developing novel genotypes in medicinal plants

Developing rice tolerance to abiotic stress through gene editing technologies

Optimized cuvette-based electroporation of buffalo and caprine zygotes supports the delivery of up to 21 kilobase plasmids

The advent of precise genome editing technologies has revolutionized the capacity to manipulate animal genotypes and phenotypes, offering a targeted complement to conventional selective breeding approaches. Efficient delivery of exogenous DNA into livestock embryos remains a major technical bottleneck, particularly...

From conventional breeding to gene editing: advances in biotechnological strategies for improving abiotic stress tolerance in rice