The purpose of this review article is to discuss the current treatment modalities and ongoing clinical trials regarding cardiac amyloidosis (CA), specifically transthyretin cardiac amyloidosis (ATTR-CA). Amyloidosis refers to the extracellular deposition of insoluble amyloid fibrillar proteins. When these proteins are...
Sareen Bains, Harry Atwal, Ashbir Sidhu et al.· Preprints.org· 0 citations
Rhododendron simsii var. putuoense is a coastal-endemic plant with significant ecological and genetic resource value. Although its chloroplast genome (cpDNA) was recently characterized, its mitochondrial genome (mtDNA) remains unexplored. Here, we report the first complete assembly and annotation of the R. simsii var....
Hong Zhu, Chun-Lei Yue· Frontiers in Plant Science· 0 citations
This Perspective examines the regulatory implications of AI-assisted crop improvement, using illustrative examples where deep learning models have been integrated for protein sequence and structure prediction, and the optimization or design of proteins for improved or novel functionalities.
F. Keiper, M. Sanches da Rocha, D. Beeckman et al.· Frontiers in Plant Science· 0 citations
FigureLab is a single-file, browser-based application for assembling publication-quality scientific figures from image data (microscopy, western blots, histology, gels, and clinical or specimen photographs). It runs entirely client-side with no installation, server, or internet connection required, so no image data eve...
Michael Baffour Awuah· Zenodo (CERN European Organi...· 0 citations
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Mutations in the splicing factor SRSF2 are commonly found in healthy individuals with clonal hematopoiesis (CH), where they confer a high annual clonal growth rate and an elevated risk for MDS/AML transformation [ 1 ]. Accordingly, SRSF2 mutations frequently occur in patients with myelodysplastic neoplasms (MDS, 10-15%...
Johannes Foßelteder, Gabriel Pabst, Andrea Raicht et al.· Leukemia· 0 citations
functional-standard-atlas: attenuation-corrected, territory-resolved benchmarking of variant effect predictors against saturation genome editing Software and frozen data underlying the manuscript "Measurement reliability bounds functional benchmarks and relocates where variant effect prediction fails" (N. Zhang). WHAT...
Ranking is saturated, calibration is not, and neither changes the evidence strength — code and frozen analysis set Software and frozen data underlying the manuscript "Ranking is saturated, calibration is not, and neither changes the evidence strength: an independent benchmark of splice-region variant effect predictors...
Ningyi Zhang· Zenodo (CERN European Organi...· 0 citations
Efficient biosynthesis of 1,3-PDO, a key bio-based chemical, depends on precise regulation of the host metabolic network. In this study, a heterologous CRISPR-Cas12a genome editing system was established and systematically optimized in Klebsiella pneumoniae, enabling efficient and stable genome editing (75-100% efficie...
Li Wang, Ming-Yang Zhao, Yuan-Ming Ye et al.· Bioresource Technology· 0 citations
Systematic comparison of Cas12i gene-editing tools in tomato identifies Cas-SF01 as the most efficient variant, achieving editing efficiencies comparable to conventional Cas9 at some genomic sites and providing a compact, highly specific, and versatile tool for studying gene function, engineering fruit metabolism, and...
Si-Qun Wu, Lei Zhu, Mei-Li Zhou et al.· Journal of Integrative Plant...· 0 citations
A homozygous ku70Δ mutant is constructed in a meiotic homokaryon of clear genetic background and inactivation of c-NHEJ by deleting ku70 significantly increases gene knockout efficiency and report the unexpected involvement of c-NHEJ in regulating the number of nuclei during conidiation.
Hao Wu, Jiao-Jiao Zhang, Yi Zhao et al.· Applied and Environmental Mi...· 0 citations
The results showed that higher runx2 b promoter methylation patterns significantly inhibited eGFP mRNA expression levels in the recombinant plasmid, and this approach provides a theoretical foundation and technical support for improving fish economic traits.
Fang Liang, Bi-Yu Wu, Jia-Yi Liu et al.· Zoological Research· 2 citations
Micronutrient malnutrition remains a major global nutrition problem, particularly in populations whose diets depend heavily on staple crops. Iron (Fe), zinc (Zn), and vitamin A deficiencies can adversely affect growth, immunity, cognitive development, and overall health. Crop biofortification provides a sustainable b...
Alemayehu Latera, E. Estifanos· iResearch· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
