This article analyzes the effectiveness of gene therapy in treating genetic diseases, its main molecular mechanisms, and modern technologies. Key therapeutic approaches such as gene addition, gene function restoration, gene expression silencing, and targeted genome editing are covered. The potential of modern gene deli...
Cancer therapy remains constrained by insufficient molecular specificity, intratumoral heterogeneity, and the emergence of therapeutic resistance that limit durable clinical responses. CRISPR Cas9 genome editing offers an unprecedented opportunity to directly reprogram oncogenic drivers, tumor suppressor pathways, and...
Abolfazl Saffari Natanzi, Elina Ahmadi, Sajjad Shahraki et al.· Advanced Composites and Hybr...· 0 citations
This review dissects the technological foundations and limiting factors of multiplex genome editing, focusing on guide RNA (gRNA) array engineering, delivery constraints, and scale‐dependent safety risks.
Lin-Li Wang, Yong-Bin Liu, Hong-Bing Han· Animal Research and One Heal...· 0 citations
Informing Biosafety Policies and Regulations: Gene Editing Technologies and Their Applications in Philippine Livestock and Fisheries synthesizes the science, potential applications, and biosafety implications of genome editing in animals. This inaugural NCBP | DOST BC Secretariat Technical Publication examines opportun...
The revelation of the previously unreported tragic death of a 6-year-old girl in Shanghai who received an experimental gene-edited intervention stands in stark contrast to the excitement surrounding the successful use of another experimental gene-edited intervention in an infant boy in Philadelphia just about a year ea...
Jeremy Sugarman· Molecular Therapy: Nucleic A...· 0 citations
Alphaviruses are positive-sense single-stranded RNA viruses belonging to the family Togaviridae; they are also part of the non-taxonomic group of arboviruses and constitute a group of arboviruses of major which are of great clinical and epidemiological relevance worldwide. These viruses can be broadly classified into e...
Amanda Henriques Gonçalves Marinho Gomes, Kamilly Soares de Almeida, Breno Henrique Booz Carvalho Corrêa et al.· Open Science Framework· 0 citations
Informing Biosafety Policies and Regulations: Gene Editing Technologies and Their Applications in Philippine Livestock and Fisheries synthesizes the science, potential applications, and biosafety implications of genome editing in animals. This inaugural NCBP | DOST BC Secretariat Technical Publication examines opportun...
Erythritol, as an important zero-calorie sweetener, is widely used in food, pharmaceutical, and daily chemical industries. However, its industrial production has long faced two major challenges: high raw material costs and severe foaming during fermentation, which significantly complicate process control and increase o...
Yupeng Nie, Xuebing Ren, Mingjing Yao et al.· Food Bioscience· 0 citations
This review synthesizes current advances in CRISPR-based DNA methylation editing for cancer epigenomics, critically evaluates key challenges, including off-target activity, context-dependent outcomes, delivery and durability, and outlines future directions integrating locus-specific editing with multi-omics profiling,...
Negar Sadeghi, E. Rodger, Aniruddha Chatterjee· Cellular and Molecular Life...· 0 citations
It is concluded that protein metabolism constitutes a dynamic interface connecting biochemistry, physiology, disease mechanisms, and precision health and provides a framework for understanding current biomedical applications and guiding future developments in disease prevention, diagnosis, and targeted therapy.
I. Umaru, H. Umaru, Maryam Usman Ahmed et al.· African Journal of Biochemis...· 0 citations
Stem cells are found in many organs, where they play essential roles in tissue repair and normal renewal. They have two defining properties: the ability to self-renew and the ability to differentiate into specialized cell types. This process is tightly regulated. Disruptions in stem-cell proliferation or differentiatio...
Adriana Martinez Silgado, Hans Clevers, Johan van Es· Utrecht University Repositor...· 0 citations
Across 13 prediction tasks spanning post-transcriptional regulation, RNA fate and expression output, EukaUTR models matched or exceeded the strongest external baselines on nearly all tasks, with relative improvements of up to 27.45%.
Mei Lang, Xing-Yu Fang, Ming-Xuan Chen et al.· bioRxiv· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
