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2,452 papers
Natural infection provides a more pronounced increase in both binding and neutralizing antibodies compared to vaccination alone, which might contribute to broader cross-protection against antigenically drifted variants.
The generation of chicken-derived scFv antibodies targeting the FCV VP1-CDEF' region are reported, with high-affinity clones 2B2 and 2E1 are promising candidates for rapid diagnostic test development and warrant further evaluation.
Center of Lifestyle Medicine, , School of Medicine, University of São Paulo, São Paulo, Brazil Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease characterized by persistent systemic inflammation, immune complex deposition, and multi-organ involvement. Although major therapeutic advances have succ...
Objective To characterize the timing and between-cow consistency of iron-handling transcript changes after lipopolysaccharide (LPS) exposure in primary bovine monocyte-derived macrophages. Methods Macrophages from 5 adult Holstein donor cows were exposed to Escherichia coli LPS or PBS and profiled by RNA sequencing a...
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HFYP alleviates exercise-induced fatigue through the synergistic regulation of skeletal muscle lactate metabolism and hepatic lactate-to-glucose recycling via the muscle-liver axis, which provides a solid theoretical basis for the high-value utilization of yeast protein and the development of HFYP-based antifatigue fun...
These findings expand the functional repertoire of the C39 peptidase superfamily, suggest an evolutionary connection between peptidases and glycosidases, and establish A0A126R2S0 as a candidate biocatalyst for β-galactoside processing.
This suggestive pattern converges with a phase II trial of azacitidine/carboplatin priming before anti-programmed death-ligand 1 rechallenge in ICB-resistant melanoma, supporting prospective evaluation.
The hydrophobic effect is one of the most consequential organizing principles in molecular biology, laying the foundation for explanation of concepts like protein folding, molecular recognition, membrane self-assembly and allosteric communication. Its conceptual description remains dependent primarily on a framework es...
Fusobacterium nucleatum encodes HmuF, which has been shown in vitro to bind tightly to heme, traffic the cofactor to anaerobilin synthase, and catalyze the four-electron reduction of anaerobilin. The structure of the heme-bound HmuF paralog, FldH, reveals an α-helical cap appended to the flavodoxin domain. Molecular...
The site-unspecific couplings are interpreted, which are not influenced by selection for protein folding stability, as the result of variations of global mutational or selective forces across the lineages where the proteins evolve.
Transmembrane proteins participate in numerous cellular processes, but their investigation is complicated by the compositional complexity of biological membranes. In particular, G protein-coupled receptors, which represent targets for nearly 50% of pharmaceuticals, require well-defined model membrane systems for functi...
The folding of newly synthesized proteins is assisted by an essential network of proteins known as molecular chaperones. In bacteria, the chaperones Trigger Factor (TF), DnaK/DnaJ (Hsp70 system), and GroEL/GroES (chaperonin system) are key players in proteostasis maintenance. Here, we further explore the cooperation an...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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