A diet low in FODMAP may negatively affect the gut microbiota of some Irritable Bowel Syndrome (IBS) patients, despite alleviating symptoms. This pilot study comprehensively explores the effects of a 3-week ur gut® supplementation on gut microbiota, gut health, dietary intake, sleep, mental health and quality of life (...
Ran Yan, A. Devine, J. Lo et al.· European Journal of Nutritio...· 0 citations
The NMR data confirmed that Lystar5 adopts a classic "three-finger" fold stabilized by six disulfide bonds, providing the first detailed structural and dynamic characterization of an echinoderm TFP.
A. S. Paramonov, M. Shulepko, A. M. Chernikov et al.· Russian journal of bioorgani...· 0 citations
The Generalized Langevin Equation (GLE) is an integro-differential equation of motion for a general observable of a many-body system and is rigorously derived using the projection operator formalism. In the standard derivation, a stationary canonical phase space distribution is used for the projection. Here, we derive...
Salma H. Salem, L. Tepper, Benjamin J. A. Héry et al.· 0 citations
Proteins possessing the Tubby domain (Tubby-like proteins, TLPs) are widespread in plants and represented by protein families. Although the function of TLPs is frequently associated with plant response to stresses, the mechanisms of their action are largely unknown. The recently demonstrated interaction of Tubic (Nicot...
Grigoriy G. Safronov, Artemii A. Pigidanov, R. A. Galiullina et al.· International Journal of Mol...· 0 citations
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Elevated levels of the pro-inflammatory cytokine Interleukin 21 (IL-21) contribute to the progression of autoimmune and inflammatory diseases by binding to its receptor (IL-21R) and activating detrimental signaling pathways in immune cells. Consequently, we developed a recombinant decoy receptor protein designed to com...
Sara Vazifeshenas, Zahra Hajihassan, Seyed Shahriar Arab et al.· Figshare· 0 citations
Complete ammonia-oxidizing (comammox) Nitrospira are recognized as key players in the nitrogen cycle, yet their ecological roles in extreme environments remain poorly understood. Here, we show that comammox Nitrospira occupy distinct ecological niches in Tibetan Plateau thermokarst lakes (pH 7.5–10.2) using stable isot...
Kang Song, Yuren Wang, Lu Li et al.· Nature Communications· 0 citations
Dengue-induced immunity differentially neutralizes closely related ZIKV strains, with generally stronger activity against P6-740, suggesting that viral genetic variation may influence cross-neutralization outcomes.
Jia-Yi Tan, N. Zainal, S. Abubakar et al.· Biomolecules· 0 citations
Elevated levels of the pro-inflammatory cytokine Interleukin 21 (IL-21) contribute to the progression of autoimmune and inflammatory diseases by binding to its receptor (IL-21R) and activating detrimental signaling pathways in immune cells. Consequently, we developed a recombinant decoy receptor protein designed to com...
Sara Vazifeshenas, Zahra Hajihassan, Seyed Shahriar Arab et al.· Figshare· 0 citations
Local fitting returns internally consistent KD for data incompatible with a 1:1 model; it is proposed isotherm verification and antibody validation of every preparation as minimal requirements.
E. Ershova, N. Pozdnyakova, A. Egorshina et al.· International Journal of Mol...· 0 citations
Nearly a century after Otto Warburg first described a unique phenomenon whereby tumour cells prefer the inefficient glycolytic pathway for energy generation (Warburg, 1956), the phenomenon has continued to aid researchers in exploring the tumour ecosystem, including tumour initiation, progression and targeting. Further...
Monde Ntwasa, Ekene Emmanuel Nweke, Mandeep Kaur et al.· Frontiers in Immunology· 0 citations
The crystal structure of the Ancient domain of chicken IMPACT (GgIMPACTAncient) is determined, providing the first crystallographic view of a metazoan IMPACT Ancient domain and a structural framework for testing the biochemical function of this evolutionarily conserved module.
Mirai Ido, S. Ito, T. Nishino· Crystals· 0 citations
This study harnesses the power of VQE to explore the folding behavior and low-energy conformational landscape of 15 peptides, each comprising eight amino acids, selected from the RCSB Protein Data Bank (PDB).
Ayushi, Madhvi Shakya· The Protein Journal· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
