Reductive dehalogenase homologs (RdhA) are widespread and structurally diverse across prokaryotes, but it remains unclear whether their major architectural classes differ systematically in how mobile they are, how often they transfer, where they sit taxonomically, and which habitats they occupy. We screened GTDB r220 a...
Background Schizophrenia (SCZ), bipolar disorder (BD) and major depressive disorder (MDD) are leading causes of disability, still only few biomarkers are available to optimise treatment prescription. As a matter of fact, about a third of patients suffering from these diseases do not respond to multiple pharmacological...
Chiara Fabbri, İnci Aksoylu, Sergi Papiol et al.· European Neuropsychopharmaco...· 0 citations
Collectively, ClGELP72, ClGELP11, and ClGELP74 represent promising candidates for future functional studies aimed at elucidating their potential roles in watermelon responses to M. incognita infection.
Curated dataset and analysis code for a deduplicated census of the mobilized colistin resistance (mcr) gene family in the August 2026 NCBI snapshot (AMRFinderPlus Reference Gene Catalog 2026-08-07.1). Contents. Four archives: (1) core curated datasets (1,298 → 1,106 records, 454 unique proteins, 284-protein QC-triage c...
Shilei Dong· Zenodo (CERN European Organi...· 0 citations
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Bone marrow taken from children at the time of an acute lymphoblastic leukemia (ALL) relapse differs in its metabolite composition from bone marrow taken from other children at initial diagnosis, which suggests how relapsed disease may be sustained.
Background Autism spectrum disorder (ASD) is a common, heritable, polygenic neurodevelopmental disorder, with hundreds of robustly associated risk genes and loci. Transcriptomic profiling of post-mortem cortex has identified characteristic ASD molecular signatures, including upregulation of protein folding pathways and...
Rachel L. Smith, Michael Jeffrey Gandal· European Neuropsychopharmaco...· 0 citations
Osimertinib is a third-generation, irreversible EGFR inhibitor that targets common activating EGFR mutations (ex19del and L858R) and the resistance EGFR mutation T790M. Clinical resistance to osimertinib frequently arises through the EGFR C797S mutation, which has driven the development of fourth-generation EGFR in...
Janneke J. Melis, Kirsten J. Kevenaar, J. Ytsma et al.· Frontiers in Oncology· 0 citations
A) Western blot shows FGFR1 protein levels in P-T47D and TR-T47D cells. GAPDH as loading control. (B–C) Relative expression of FGFR1 and STING1 respectively, in P-T47D and TR-T47D cells, measured by RT-qPCR and normalized to ACTB and RPLP1. Fold change was calculated relative to the geometric mean of ΔCq of the P-T47D...
Torbjørn Amundsen. Lien, Sushil Dhakal, Anne Marthe. Fosdahl Wium et al.· 0 citations
Since its discovery in 2016, the RNA-targeting CRISPR-Cas13 protein is widely adopted for precise knockdown of target RNAs in human cells. However, conflicting reports from different groups over the years raised questions about the specificity of Cas13 knockdown. The ambiguity largely stems from the fact that the exact...
Code and processed data release accompanying the manuscript “eQTL weight-source choice reshapes TWAS gene candidacy: a two-axis dual-source audit with disease-agnostic calibration and a genome-wide benchmark” (BMC Genomics submission). v2.2.0 (2026-09-11) — numerically stable ACAT-O, fixed-threshold and architecture-un...
Yijing Wu, Mingwei Chen, Qiuyan Wu et al.· Zenodo (CERN European Organi...· 0 citations
Curated dataset and analysis code for a deduplicated census of the mobilized colistin resistance (mcr) gene family in the August 2026 NCBI snapshot (AMRFinderPlus Reference Gene Catalog 2026-08-07.1). Contents. Four archives: (1) core curated datasets (1,298 → 1,106 records, 454 unique proteins, 284-protein QC-triage c...
Shilei Dong· Zenodo (CERN European Organi...· 0 citations
Occupational heat and blast overpressure impair spermatogenesis, and whether repair capacity supplied from outside the germ cell can lift the resulting block has not been tested. GC-2 spermatocytes received 1000 shock-wave pulses then 100°C for 40 s, and C57BL/6 mice received a 10% methane blast with intratesticular te...
Jiahua Meng, Zitong Zhang, Ning Li et al.· Figshare· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
