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2,452 papers
Analysis of transcriptomic patterns in a dilated cardiomyopathy (DCM) dataset and pan-cancer data only for descriptive context did not establish ferroptosis as a causal mechanism, biomarker, or treatment target in primary HHD.
Pancreatic beta cells face exceptional protein folding demands from high insulin production requirements, placing extraordinary stress on the endoplasmic reticulum (ER) and contributing to dysfunction in diabetes pathogenesis. Monitoring ER stress dynamics in living cells remains challenging due to the destructive natu...
Background Schizophrenia (SCZ) and bipolar disorder (BD) share considerable genetic risk andoverlap in clinical presentation, yet the nature and extent of their molecular convergence, particularly in relation to illness progression, remains insufficiently defined. Cerebrospinal fluid(CSF) proteomics offers a minimally...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked molecular and epithelial heterogeneity, but the cross-cohort and cellular context of candidate genes remains incompletely resolved. We integrated bulk transcriptomic and proteomic data with patient-grouped machine-learning assessment, independent-cohort...
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These PL-NPs, which were characterized by controlled release, specific schistosoma-targeting, potent anti-schistosomal efficacy, and hepatoprotective activity, offer a promising therapeutic strategy for schistosomiasis.
HSPA5 is a member of the HSP70 family of heat shock proteins (HSPs) and functions as a chaperone protein within the endoplasmic reticulum (ER). It plays a role in maintaining ER homeostasis, assists in correct protein folding, and triggers the unfolded protein response. Environmental toxins–such as heavy metals, microp...
Occupational heat and blast overpressure impair spermatogenesis, and whether repair capacity supplied from outside the germ cell can lift the resulting block has not been tested. GC-2 spermatocytes received 1000 shock-wave pulses then 100°C for 40 s, and C57BL/6 mice received a 10% methane blast with intratesticular te...
Protein hydrogels are promising artificial extracellular matrices (ECMs) for 3D stem cell and organoid culture due to their favorable stress relaxation behavior (a decrease in stress in response to strain). Inter-chain entangled motifs, in which different protein chains are interlaced, represent a powerful strategy t...
PAIRWISE: Deep Learning-based Prediction of Effective Personalized Drug Combinations in CancerPAIRWISE predicts whether a drug pair acts synergistically in a specific tumour sample. It fuses three modalities — molecular graphs of the two compounds, theirdrug–target interaction profiles propagated over a protein–protein...
Background Genome-wide association studies (GWAS) have identified dozens of loci for autism and related neurodevelopmental disorders (NDDs), yet pinpointing causal variants remains challenging. Standard fine-mapping assumes the causal variant is a SNP present in reference panels, but common structural variants (SVs)—de...
Abstract Nattokinase (NK) is an orally administered subtilisin-family serine protease with reported activity across multiple interconnected proteolytic and cardiovascular targets, including degradation of SARS-CoV-2 spike protein, fibrinaloid amyloid microclots, fibrin clots, and classical amyloid substrates; enhanceme...
Since its discovery in 2016, the RNA-targeting CRISPR-Cas13 protein is widely adopted for precise knockdown of target RNAs in human cells. However, conflicting reports from different groups over the years raised questions about the specificity of Cas13 knockdown. The ambiguity largely stems from the fact that the exact...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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