AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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2,530 papers
The self-assembly of the cholesterol-dependent cytolysin Perfringolysin O (PFO) into stable transmembrane nanopores composed of 46 ± 9 monomers is reported, enabling, for the first time, resistive-pulse-based characterization of intact virus particles and ribosomes with a biological nanopore.
Figure S1. Determination of NAC treatment concentration and subcellular localization analysis of SBP. Survival rates of Hep-2 (A) cell after 2 h treatment with different concentrations of NAC, with untreated cells as controls. Western blot analysis of MUC5AC expression in Hep-2 (B) cell after 2 h treatment with serial...
A cysteine-inspired conjugated polymer photosensitizer was developed to integrate enhanced tumor accumulation, hydrogen sulfide generation, photodynamic therapy (PDT), and photothermal therapy (PTT), achieving an 89% tumor inhibition rate without detectable skin injury or systemic toxicity.
Overall, this work demonstrates that rational mutagenesis can alter polyesterase activity against structurally distinct biodegradable polyesters, providing potential mechanistic insights to guide the development of specialized biocatalysts for targeted polyester degradation.
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This study provides a resource for redefining precision-breeding paradigms by harnessing cryptic 3D chromatin targets by decoupling sequence-level from chromatin-level selection and shifting the subgenome expression balance of 39 homoeologs in cultivated cotton.
Smart, programmable membrane-engineered nanosponges (ACNPs) displaying high-density ACE2 and encapsulating the viral entry inhibitor camostat enforces sequential recognition and endocytosis blockade, offering a deployable, non-invasive, universal strategy for early intervention against pan ACE2-dependent coronaviruses...
A mechanistic framework for the active regulation of SARS-CoV-2 RNA architecture is established and a multilayered host-virus regulatory axis that modulates viral genome heterogeneity is revealed.
In Chinese patients with cirrhosis, lack of early clinical response to empiric antibiotics independently predicts short-term mortality and is associated with a higher risk of clinically distinct secondary infection.
This work identifies key sequence-level features predictive of intron retention in Tetrahymena and could provide a generalizable, explainable ML framework for investigating splicing regulation in other eukaryotes.
Industrial biocatalytic applications are frequently constrained by poor recombinant enzyme solubility and limited functional recovery in conventional microbial expression systems. To address this challenge, we developed a baculovirus–insect cell whole-cell biocatalysis platform and evaluated its feasibility using N-ace...
In recent years, the number of known protein structures has increased significantly. Predictive algorithms and experimental methods provide the global topology and fold of proteins with high accuracy. However, the local quality of the protein structures, including bond lengths, angles, and positions of individual atoms...
Abstract The folding and assembly of nucleic acids are traditionally described in terms of intrinsic base pairing, stacking interactions, and topological constraints. However, in cellular environments, these energy landscapes are continuously reshaped by multivalent protein binding. In this chapter, we present a unifie...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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