Roles of FGF23 in P homeostasis in a large animal, healthy swine model were validated, with HP consumption stimulated bone FGF23 expression and renal adaptive responses in healthy pigs, consistent with roles of FGF23-mediated phosphaturia and regulation of vitamin D metabolism for maintenance of P homeostasis.
M. Grez-Capdeville, Brittney P. Kokinos, L. Amundson et al.· JBMR Plus· 0 citations
A mechanistic model in which selectivity for aggregated aSyn arises from an emergent mesoscale interface combining a polyelectrolyte brush with recurrent core hotspots is presented, establishing full‐length, brain‐derived fibril ensembles as a practical framework for understanding ligand recognition at amyloid surfaces...
Carlos Pintado-Grima, Oriol Bárcenas, G. Tesei et al.· Protein Science· 0 citations
MIRAGE (Measuring Interpolation and Redundancy in Affinity GEneralization), a plug-in benchmark treating historical public family support (through 2019) as an explicit variable, applying a family-support axis to affinity and pose prediction via matched strata, family-disjoint controls, ligand-only baselines, and tempor...
Mehdi Yazdani-Jahromi, Sanjay Padhi, Ivan Garibay· 0 citations
SoupFold is introduced, which improves co-folding predictions by learning simple mappings between the representation spaces of co-folding models, and achieves state-of-the-art performance on both protein-protein and protein-ligand structure prediction.
Hyosoon Jang, Taewon Kim, Sungsoo Ahn· 0 citations
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CHRAC17, a key coordinator of chromatin remoder and DNA polymerase ε (Polε), orchestrates sequential chromatin remodeling, nucleosome assembly and sliding, to promote RAD51-mediated HR and mobilize Polε, thereby ensuring genome stability.
It is shown that ESM-2 exhibits reduced attention on disordered regions, yet still encodes meaningful biological signals, and that both the radius of gyration and individual dynamic contact maps, key characteristics of IDPs, can be obtained from the model logits and embeddings.
Lauren Naworski, Lydia L. Good, Rob M. Scrutton et al.· bioRxiv· 0 citations
Mutations in the splicing factor SRSF2 are commonly found in healthy individuals with clonal hematopoiesis (CH), where they confer a high annual clonal growth rate and an elevated risk for MDS/AML transformation [ 1 ]. Accordingly, SRSF2 mutations frequently occur in patients with myelodysplastic neoplasms (MDS, 10-15%...
Johannes Foßelteder, Gabriel Pabst, Andrea Raicht et al.· Leukemia· 0 citations
Abstract Luciferases are widely used bioluminescent reporters, yet access to these enzymes has historically relied on recombinant expression. Using automated fast-flow peptide synthesis (AFPS), we synthesized Gaussia luciferase (GLuc, 18.1 kDa, 168 amino acids), picALuc (13 kDa, 120 amino acids), and LuxSit-i (13.8 kDa...
David Sarabia-Castillo, Amanda E. Cowfer Chavez, Sunit Pal et al.· The Journal of Organic Chemi...· 0 citations
Abstract – Development of a Wound Healing Bioactive Rutin-Enriched Poly-Herbal Hydrogel Matrix: In Silico Mechanism and In Vivo(In Vivo done by Insilico AI) Acceleration of Diabetic Wound Healing Events Background: Diabetic wound pathogenesis involves sustained inflammation, oxidative stress, poor angiogenesis, bacteri...
Shibanjan Paul Roy· Zenodo (CERN European Organi...· 0 citations
Epistasis predicted by enzyme-constrained metabolic models is computed at a single value of the protein available to metabolism, although that amount varies two- to three-fold with growth rate. We ask how epistatic interactions are affected by computing every single and pairwise gene deletion in an enzyme-constrained m...
Eivind Almaas, Tjaša Kumelj· bioRxiv (Cold Spring Harbor...· 0 citations
Supplementary single-cell sequencing and protein quantification maps. Supplementary Figure S1. Marker-gene expression across annotated cell types.Dot plot showing representative marker-gene expression across the annotated cell types in GSE135893. Dot size indicates the percentage of cells expressing each gene, whereas...
Shuangshuang Li· Zenodo (CERN European Organi...· 0 citations
ESMCHalo is a frozen protein-sequence predictor that combines ESMC-600M layer-36 canonical mean representations with five compact student heads trained using out-of-fold teacher targets with documented cross-fold limitations. The release provides frozen inference code, model checkpoints, calibration, a fixed threshold,...
Fang Lv, Hutao Jin, Qishuai Ma et al.· Zenodo (CERN European Organi...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
