AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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2,530 papers
It is posited that miRNAs hold significant potential both as novel therapeutic targets and as pivotal regulators in deciphering the intricate pathogenesis of COVID-19 and requires the synergistic integration of in vivo and in vitro experimental approaches in conjunction with rigorous clinical investigations.
Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices. While these residues are predom...
Peptide receptor radionuclide therapy with [177Lu]Lu-DOTATATE is an established treatment for somatostatin receptor–expressing neuroendocrine tumors. Although strong anti-tumor effects have been demonstrated in experimental models, curative responses in patients remain limited. Improved understanding of the molecular r...
This thesis is devoted to the mechanical and topological properties of DNA, the repository of our genetic information. These properties are fundamental to abroad range of biological processes, essentially setting the ground rules for the organization of DNA and its interactions with the cellular machinery. We study phy...
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The results indicate that in vitro TGF-β2 inhibition effectively reduces gene expression that can be significant for better targeting of hypoxia-modified cancer cells.
It is demonstrated that forced intercalation can convert an RNA-binding peptide into a fluorogenic probe for ligand-displacement analysis and direct RNA detection.
This study evaluated the combined effects of ultrasound-assisted hydration (25 kHz, 38 W/L, 20 min, 25 °C), followed by germination (72 h at 25 °C), and ultrasound-assisted mashing performed under 0 %, 50 %, or 100 % ultrasound application during each isothermal resting stage (25 kHz, 38 W/L, 25 °C). The effects of the...
It is suggested that IPF pathogenesis creates a permissive microenvironment for PFD through simultaneous enhancement of paracellular permeability and active cellular uptake through simultaneous enhancement of paracellular permeability and active cellular uptake.
The sensitivity and specificity of ADC1 support its potential use as a diagnostic Ag for anaplasmosis and are consistent with AlphaFold v2 predictions, which further predict the core of P44 to be an eight-stranded β-barrel.
The structures of complexes formed by covalently linking CppB and CppA by X-ray crystallography and cryo-EM analysis allowed us to construct a three-dimensional structure model with dynamic motion of C. perfringens pili, and proposed new insights into the mechanism by which CppB is preferentially attached to CppA.
Full‐length atomistic conformational ensembles generated by IDPConformerGenerator and optimized by X‐EISDv2 workflow support a model of translation regulation in which the dynamic 4E‐BP2:eIF4E complex facilitates accessibility of regulatory sites of 4E‐BP2 when bound.
Late lactation is frequently accompanied by changes in goat milk composition and volatile-related quality, which may reduce its commercial value. This study investigated whether Astragalus polysaccharide (APS), a plant-derived bioactive polysaccharide from Astragalus membranaceus (Fisch.) Bunge, is associated with milk...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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