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2,530 papers
Supplementary single-cell sequencing and protein quantification maps. Supplementary Figure S1. Marker-gene expression across annotated cell types.Dot plot showing representative marker-gene expression across the annotated cell types in GSE135893. Dot size indicates the percentage of cells expressing each gene, whereas...
An AP-MS strategy based on direct infection with an epitope-tagged chikungunya virus (CHIKV/myc-E2) is introduced, which is used to successfully uncover two new antiviral factors in CHIKV cellular reservoirs-macrophages.
Optimizing the application of light is a central challenge in the cultivation of cyanobacteria because light is needed for growth, but excessive light can cause cellular damage. Here, we demonstrate that the temporal pattern of the light intensity, rather than the time-integrated daily total, determines photosynthetic...
Human γS-crystallin is a highly soluble protein found in the eye lens, where it is densely packed with other proteins to form the refractive tissue required for vision. Mutations in γS can compromise its solubility and cause congenital cataract, while post-translational modifications (PTMs) can lead to age-related cata...
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Abstract Light-activated drugs are a promising way to treat localized diseases for which existing treatments have severe side effects. However, their development is complicated by the set of photophysical and biological properties that must be simultaneously optimized. Here we used computational techniques to find a se...
Motivation: Enzymes with unrelated folds can share identical catalytic mechanisms through convergent evolution, yet aligning known catalytic sites across non-homologous proteins remains challenging. General-purpose structural aligners optimize global backbone similarity and sacrifice local catalytic geometry, while ded...
Findings advance the mechanistic understanding of exoprotein-mediated stabilization in anammox granules and provide valuable implications for optimizing the performance of anammox systems.
It is presented that cooperative micellization of aptamer-derived PROTAC could overcome the cellular internalization barrier, enabling potent intracellular sclerostin degradation and TNBC therapy.
In both dextran sulfate sodium‐induced colitis and IL‐10‐deficient spontaneous colitis mouse models, L. reuteri@ZGM persistently scavenged ROS, effectively reduced pro‐inflammatory cytokine levels, restored the expression of tight junction‐associated proteins and intestinal barrier function, enhanced probiotic coloniza...
A comprehensive computational study was performed to gain insight into the details of the mechanism and the order of the reaction steps of the mycobacterial Rv0097 isonitrilase to find antibacterial treatments against Mycobacteria.
A hypothesis-generating in silico approach provides a framework for experimental validation of lncRNA-mediated regulation in diabetes-related signalling pathways by identifying structurally plausible RNA–protein interaction interfaces that overlap with known regulatory hotspots in YAP1.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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