AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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2,530 papers
This work used site-directed mutagenesis in an extensive manner to study the role of the highly conserved isoleucine 563 of Thermococcus sp.
An antitumor peptide-based delivery platform in which both termini of a stapled p53 α-helix are linked via a disulfide bond, thereby repurposing nonpolar residues originally involved in target protein (hDM2) binding as a hydrophobic block that drives co-assembly with doxorubicin.
In this study, the synergistic cryoprotective efficacy of chicken skin collagen (CSC) and tamarind seed polysaccharide (TSP) was evaluated using hairtail surimi subjected to five freeze-thaw (F-T) cycles. It was revealed that 0.5% CSC and 0.5% TSP (CSC-TSP) composite significantly outperformed individual components and...
It is demonstrated that ZSWIM6 is a key transcriptional regulator and that allele-specific disturbances drive the marked clinical heterogeneity of ZSWIM6-related disorders.
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This systematic narrative review aims to synthesize the available evidence on the role of protein sorting machinery in CFTR channelopathies and its contribution to exocrine pancreatic dysfunction to improve pancreatic function and mitigate disease progression.
Discussion and ConclusionThe (ELUULK) 4 3 10 -helical bundle displays strongly position-dependent mutational tolerance.Surface residues can be readily substituted while preserving the 3 10 architecture, whereas the interfacial Aib positions and hydrophobic core impose much tighter geometric constraints.Computational an...
Global aquaculture has grown significantly, but to maintain current consumption, supply must double over the next 20 years. Here, we characterised the digestive and absorptive capacities in the intestines of three commercially important, farmed fish species with varying natural diets: Nile tilapia (Oreochromis niloticu...
A cationic nanobubble formulation capable of efficient DNA loading and ultrasound-dependent gene expression is presented, supporting a mechanism for selective and site-specific gene delivery.
Abstract: This paper and accompanying master dataset present a complete, first-principles derivation of the fine-structure constant ($\alpha$) and unified energy states, bypassing standard quantum electrodynamic (QED) infinities and empirical curve-fitting. Utilizing a deterministic, non-Cartesian charge-pond framework...
This archive contains the complete analysis notebook (canlung_dissociation_final.ipynb) accompanying Jacobs, Detectable and Lethal Lung Cancer Are the Same Proteomic Disease (2026), the third study in a trilogy examining whether the circulating proteins that predict cancer detection differ from those that predict cance...
This archive contains the complete analysis notebook (canlung_dissociation_final.ipynb) accompanying Jacobs, Detectable and Lethal Lung Cancer Are the Same Proteomic Disease (2026), the third study in a trilogy examining whether the circulating proteins that predict cancer detection differ from those that predict cance...
Intrinsically disordered regions (IDRs)-the proteome dark matter-confer dynamic adaptability upon rigid protein scaffolds. How IDRs and their adjacent folded domain (context) modulate enzyme substrate promiscuity and calibrate host-specific immune outputs remains unknown. Addressing this knowledge gap has substantial e...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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