Scientific descriptions become useful through the work they let us do next: predict a response, combine observations, or reuse a result. A correct answer to one question can nevertheless discard a distinction that the next question requires. This paper develops RPRM Process Mechanics as a human-guided method for findin...
William J. Foster· Zenodo (CERN European Organi...· 0 citations
F-box proteins are important components of the SCF-E3 ubiquitin ligase complex, specifically regulating target protein abundance and participating in plant growth, development, and stress responses. In this study, an F-box gene responsive to salt stress, SmAMR1 , was cloned from Salix matsudana Koidz. It was 1209 bp lo...
Lei Wang, Junkang Zhang, Han Zhao et al.· Industrial Crops and Product...· 0 citations
The study assessed changes in energy, temporal, technological, environmental, and washing-quality parameters after introducing a central heat recovery system in an industrial laundry. Instrumental measurements, gravimetric and microbiological methods, textile mechanical testing, and calculations of energy-efficiency an...
Conformational conversion of the cellular isoform of prion protein, designated PrP C , into the abnormally folded, amyloidogenic isoform, PrP Sc , plays a key pathogenic role in prion diseases, including Creutzfeldt-Jacob disease in humans. We previously reported that sortilin, a member of the vacuolar protein sorting...
Batzaya Batchuluun, Hironori Miyata, Nandita Rani Das et al.· Scientific Reports· 0 citations
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NADPH-cytochrome P450 reductase (CPR) serves as the obligate electron donor for cytochrome P450 enzymes and is essential for xenobiotic metabolism and detoxification. However, its involvement in insecticide resistance of Aphis spiraecola remains unclear. In this study, the open reading frame (ORF) of the A. spiraecola...
Shuo Zhang, Kang Wang, Yi You et al.· Frontiers in Physiology· 0 citations
Depression has a substantial genetic component. Protein folding and proteostasis pathways have been implicated in depression-related biology, but the genetically supported associations between specific protein folding-related genes and major depressive disorder (MDD) remain insufficiently understood. We applied summary...
Juan Wang, Shen He, Jun-Fang Cui et al.· Annals of General Psychiatry· 0 citations
Ataxia-telangiectasia (A-T) is a multisystemic genetic disorder caused by pathogenic mutations in the ATM gene, with effects extending beyond the canonical DNA damage response. We investigated whether two compact ATM transcript variants, ATM 4-53 (exons 4 and 53 joined) and ATM SINT (an in silico-designed ATM variant),...
Anastasia Ricci, Federica Biancucci, G. Morganti et al.· International Journal of Mol...· 0 citations
ALKBH5 is identified as a candidate host-cell engineering target for improving recombinant protein production and support further validation under industry-relevant fed-batch conditions.
Overall, this study demonstrates that salmon skin LMWCPs were cytocompatible within the tested concentration range and modulated several ECM-related genes, providing a preliminary basis for future protein-level, functional, and translational evaluation.
Sottawat Benjakul, Krisana Nilsuwan, Umesh Patil et al.· International Journal of Mol...· 0 citations
Scientific descriptions become useful through the work they let us do next: predict a response, combine observations, or reuse a result. A correct answer to one question can nevertheless discard a distinction that the next question requires. This paper develops RPRM Process Mechanics as a human-guided method for findin...
William J. Foster· Zenodo (CERN European Organi...· 0 citations
This study reports a series of CRBN molecular glues that selectively induce proteasomal degradation of VAV1, a hematopoietic-specific signaling protein and key target in hematological malignancies and autoimmune diseases. Using unbiased global proteomics, we identify phenyl-glutarimide derivatives (e.g., NGT-201-12) as...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
