The pancreas consists of exocrine and endocrine compartments. In the exocrine pancreas, cystic fibrosis transmembrane conductance regulator (CFTR) functions mainly in ductal epithelial cells as a chloride and bicarbonate channel. Its activity depends on proper protein folding, trafficking, and localization to the apica...
Aime Patrick Niyomugabo, Leopold Ntakirutimana, Abdullateef Isiaka Alagbonsi· Figshare· 0 citations
Although affinity prediction of protein–ligand binding remains an important challenge, cofolding models are expected to make virtual screening more effective for drug discovery and development. To verify the effectiveness of selecting a tractable number of candidates from a compound library using cofolding models, we s...
Shinya Kawano, Akira Ikari, Satoshi Endo et al.· Journal of Chemical Informat...· 0 citations
A source-traceable documentary companion on SFT's operational foundation, exact inverse-alpha construction, finite clock/quantum/interaction composition, computational applications, consciousness criterion, contribution history and institutional position. Includes a scientific audit inventory and unchanged existing adm...
Maria Smith· Zenodo (CERN European Organi...· 0 citations
The pancreas consists of exocrine and endocrine compartments. In the exocrine pancreas, cystic fibrosis transmembrane conductance regulator (CFTR) functions mainly in ductal epithelial cells as a chloride and bicarbonate channel. Its activity depends on proper protein folding, trafficking, and localization to the apica...
Aime Patrick Niyomugabo, Leopold Ntakirutimana, Abdullateef Isiaka Alagbonsi· Figshare· 0 citations
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A novel aptamer-based fluorescent sensor using Lettuce indicator, a light-up DNA aptamer that adopts a precise three-dimensional structure, which enables it to selectively bind and activate the otherwise non-fluorescent small-molecule fluorophore, generating a target-dependent fluorescent signal.
Xin Ji, Ran-Ran Hou, Hai Bao et al.· Analytical Chemistry· 0 citations
Chiral molecules can differ substantially in biological potency, yet the extent to which this stereochemical discrimination varies across protein families has not been systematically measured. Here, same-assay enantiomer pairs were extracted from ChEMBL 37 to construct an archive-scale, target-family-stratified distrib...
Dylan Ashraf· Journal of high school scien...· 0 citations
Targeted molecular imaging utilizing positron emission tomography (PET) technology may provide a non-invasive biomarker in idiopathic pulmonary fibrosis (IPF). Translocator protein (TSPO, 18 kDa), a mitochondrial outer membrane protein, is upregulated in persistent injury and inflammation. Hence, we evaluated the TSPO-...
Tejaswini Kulkarni, Padma Manapragada, Jamie R. Davison et al.· BMC Pulmonary Medicine· 0 citations
HNF-4α inhibits HCC cell proliferation and invasion and promotes apoptosis through negative regulation of the IGFBP-2/Notch1 signaling pathway, providing new experimental evidence for the tumor-suppressive mechanism of HNF-4α in HCC.
Chang-Xi Liao· Pakistan Journal of Pharmace...· 0 citations
A source-traceable documentary companion on SFT's operational foundation, exact inverse-alpha construction, finite clock/quantum/interaction composition, computational applications, consciousness criterion, contribution history and institutional position. Includes a scientific audit inventory and unchanged existing adm...
Maria Smith· Zenodo (CERN European Organi...· 0 citations
Corrected edition 1.1: Read the paper with its full linked bibliography and publication catalogue. The original edition remains available below.A source-traceable documentary companion on SFT's operational foundation, exact inverse-alpha construction, finite clock/quantum/interaction composition, computational applicat...
Maria Smith· Zenodo (CERN European Organi...· 0 citations
Among phage-derived antimicrobial molecules, holins are membrane-active proteins that play a central role in bacterial lysis; however, the contribution of their individual structural domains to antibacterial activity remains poorly understood. In this study, we investigated the functional role of the extended C-termina...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
