A structure dynamics-based design strategy is reported that transforms OB into a selective antibacterial agent through rational modification of the nitrophenyl moiety, and establishes a 'kinetic sensor' strategy for achieving species selectivity.
A hydrogel microsphere-based CHA method that integrates CHA signal amplification with the solid-phase carrier of hydrogel microspheres for the detection of miRNAs in blood samples with favorable application potential for the detection of miRNA biomarkers in complex biological samples with a simple, low-cost, enzyme-fre...
Nai Liu, Chun-Guang Yang, Zhang-Run Xu· Analytical Methods· 0 citations
Suboptimal vitamin D status is highly prevalent among IBD patients in Misurata, Libya, with disease activity acting as the primary driver of vitamin D depletion regardless of patient gender, underscoring the critical need for continuous assessment and the implementation of effective supplementation strategies to improv...
Omaima Ben Krayem· Attahadi Medical Journal· 0 citations
Repeat proteins fold through pathways that are strongly shaped by local energetics, making them highly sensitive to mutations. The ankyrin repeat (AR) domain of IκBα is a cooperative folding unit in which the first four repeats (AR1–AR4) are stable, while the last two are destabilized. Despite this simple modular archi...
Murilo N. Sanches, María Inés Freiberger, Peter G. Wolynes et al.· Zenodo (CERN European Organi...· 0 citations
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Temporal Wave Function Collapse Dynamics explores the theoretical underpinnings of the collapse of temporal wave functions – fundamental units of information within complex systems such as neural networks and protein folding – as a dynamic process. This paper posits that collapse isn't a discrete event but rather a con...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
Using NMR, molecular dynamics simulations, and complementary kinase and binding assays, it is shown that Val234 acts as a crucial allosteric hub of PKG autoinhibition, explaining how distal mutations can unpredictably rewire kinase allostery and drive pathogenic vascular signaling.
Karla Martinez Pomier, Leopold Jahn, B. VanSchouwen et al.· Science Advances· 0 citations
Dynamic Symmetry Field Analysis (DSFA) is a novel technique for unraveling the intricate patterns within complex systems, specifically focusing on identifying and quantifying 'dynamic symmetry fields.' This research explores the potential of employing a new mathematical operator to analyze the evolution of these fields...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
Overview A prospectively frozen benchmark suite for leakage-safe multi-omic integration. It evaluates predictive performance, modality utility, null behavior, failure handling, and compute cost without making claims of clinical utility or causal biological inference. Included datasets Synthetic controls: paired null an...
TUNA BİRGÜN· Zenodo (CERN European Organi...· 0 citations
Overview A prospectively frozen benchmark suite for leakage-safe multi-omic integration. It evaluates predictive performance, modality utility, null behavior, failure handling, and compute cost without making claims of clinical utility or causal biological inference. Included datasets Synthetic controls: paired null an...
TUNA BİRGÜN· Zenodo (CERN European Organi...· 0 citations
Colorectal cancer (CRC) is a widespread health issue that attains high mortality. The adaptor protein SH3BP2 amplification results in metabolic changes, oxidative stress, NK cell activity, and inflammation. The NK cells are capable of destroying tumor cells without prior activation, help prevent metastasis, and have pr...
This research investigates the application of non-linear constraint optimization to biological systems, specifically focusing on optimization of gene expression and protein folding. Traditional optimization methods often struggle with the inherent complexity and dynamic nature of biological systems, necessitating novel...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
Dynamic Symmetry Field Analysis (DSFA) is a novel technique for unraveling the intricate patterns within complex systems, specifically focusing on identifying and quantifying 'dynamic symmetry fields.' This research explores the potential of employing a new mathematical operator to analyze the evolution of these fields...
Jincheng Zhang· Zenodo (CERN European Organi...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
