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2,550 papers
Molecular dynamics (MD) simulations are a fundamental tool in materials science, biology, and pharmaceutical research, offering insights into molecular behavior and dynamics. However, traditional MD simulations often suffer from limitations in accuracy and efficiency, particularly when dealing with complex, dynamic env...
Colorectal cancer (CRC) is a widespread health issue that attains high mortality. The adaptor protein SH3BP2 amplification results in metabolic changes, oxidative stress, NK cell activity, and inflammation. The NK cells are capable of destroying tumor cells without prior activation, help prevent metastasis, and have pr...
Researchers at Zhejiang University in China and Imperial College London in the UK built standalone tunnelling electrodes with an average gap of 1.6 nm at the tip of a nanopipette, and used them to identify single nucleotides and proteins electrically. By combining the probes with dielectrophoretic (DEP) trapping, which...
Researchers at Zhejiang University in China and Imperial College London in the UK built standalone tunnelling electrodes with an average gap of 1.6 nm at the tip of a nanopipette, and used them to identify single nucleotides and proteins electrically. By combining the probes with dielectrophoretic (DEP) trapping, which...
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Derived data, run outputs and figure source data supporting the article "Joint optimisation of amino acid and coding sequence for de novo designed proteins". Includes the inverse-folding marginals for all 862 backbones and the full 230,992-row double-mutant additivity table.
Alfalfa biomass contains significant carbohydrate fractions underutilized in animal feed. This research optimized the enzymatic hydrolysis of Alfalfa biomass and evaluated single-cell protein (SCP) production using Candida utilis and Komagataella pastoris . Hydrolysis kinetics in this study showed biphasic sugar releas...
Glucoamylases are highly demanded by the industry for starch saccharification, which necessitates an increase in enzyme activity. To improve the activity of Aspergillus awamori VKPM F-1262 glucoamylase N181Q (AGAM), amino acid substitutions were made in the region of substrate binding. In the case of the variant D237G,...
Findings establish PtoeIF5A1 in poplar as a pleiotropic regulator integrating developmental cues, programmed cell death, and stress responses; and as a valuable genetic resource for breeding stress-resilient woody plants.
Abstract Probiotic efficacy depends not only on gastrointestinal survival but on mucosal adhesion and the capacity to deliver bioactive molecules at the intestinal surface. This study optimized a whey protein isolate (WPI)–chitosan (CS) matrix for spray drying microencapsulation of Lacticaseibacillus casei BL23 using c...
Overall, SH3BP2 plays a key role in cancer growth and immune regulation, making it a promising target for CRC therapy, and further experimental validation is needed to demonstrate its diagnostic and therapeutic potency.
Protein language models (pLMs) learn sequence patterns at evolutionary scale, but these patterns remain inaccessible within these “black box” models. To discover them, we developed MotifAE, an unsupervised framework based on the sparse autoencoder (SAE) architecture that projects pLM embeddings into an interpretable, s...
This is an updated version of a presentation at Edinburgh University in June with some editing and additional slides on BindingDB patent curation Presented at the Scaggs School of Pharmacy, University of California San Diego, August 28th 2026 as guest of Prof. Michael Gilson Abstract The beta amyloid (APP) cleaving enz...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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