protein folding

Rapidly evolving aphid gall effector proteins exhibit saposin-like folds.

Many insects manipulate plants by injecting effector proteins. In one extreme example of this molecular "hijacking," Hormaphis cornu aphids inject bicycle proteins into Hamamelis virginiana, contributing to the development of novel organs called galls. Bicycle proteins share no amino acid sequence similarity with prote...

Omicau Multi-Omics Benchmark Suite

Overview A prospectively frozen benchmark suite for leakage-safe multi-omic integration. It tests predictive performance, modality utility, model-capacity effects, missingness handling, null behavior, exploratory external transport, and failure handling without making claims of clinical utility or causal biological inf...

Omicau Multi-Omics Benchmark Suite

Overview A prospectively frozen benchmark suite for leakage-safe multi-omic integration. It tests predictive performance, modality utility, model-capacity effects, missingness handling, null behavior, exploratory external transport, and failure handling without making claims of clinical utility or causal biological inf...

Artificial intelligence is reshaping neuroscience across scales.

Recent progress is reviewed in applying AI for neuroscience along this scale axis: structure prediction for proteins, simulation-based inference for biophysical neurons, latent and dynamical models for neural populations, task-trained networks as minimal models of circuit computation, computer vision for animal behavio...

Gill acetylcholinesterase activity and condition index in Donax rugosus as candidate biomarkers of coastal water quality in Mauritania

Coastal waters off Nouakchott support fisheries and, more recently, offshore oil activity and iron-ore export, all of which raise the risk of marine contamination. Local biomonitoring tools are still lacking. We asked whether the wedge clam Donax rugosus , abundant on Nouakchott’s beaches, can serve as a sentinel. Acet...

Hyper-Fold: Exploring the Expressive Limit of Sequence-Geometry Learning for Proteins via Hypergraph Modeling

Hyper-Fold is introduced, a rank-K separable convolutional backbone approaching this ceiling at message-passing cost, suggesting that a sufficiently expressive 3D backbone recovers information that fusion architectures previously borrowed from evolution-scale pretraining.

Post-print gold nanometallization tunes the architecture-dependent chemomechanics of 4D protein microstructures

The radical that was never seen: one added hydrogen bond opens up the photoactivation mechanism of a blue-light receptor

A collaboration between researchers in the United States, the United Kingdom and Hungary has mutated the amino acid sequence of the AppA BLUF domain, a blue-light photoreceptor, and succeeded in capturing the proton-coupled electron transfer (PCET) radical intermediates that had never been observed in this protein. By...

The interaction between NC(p7)1-55 and p6 may regulate interactions with nucleic acids during assembly through modulation of Gag folding

Experimental evidence of a direct protein-protein interaction between p6 and the N-terminal region of NC(p7)1-55 is brought and this suggests that p6 could modulate the recognition of the viral genomic RNA (gRNA) by interacting with NC(p7)1-55 during assembly and be a key player in this process.

Supplementary Tables S1-S16 from Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate

Supplementary Table 1. Clinical metadata Supplementary Table 2. 3D stacked serial sections overview Supplementary Table 3. 2D gene discovery sections overview Supplementary Table 4.CODEX panel information Supplementary Table 5. Xenium panel information Supplementary Table 6. HT704B1 distant region path metadata Supplem...

Engineering Caspase-Activated DNase for Nucleosome-Resolution Chromosome Conformation Capture

Chromosome conformation capture methods such as Hi-C and Micro-C have transformed our understanding of genome organisation, revealing architectural features from megabase-scale compartments to kilobase-scale loops. Yet the choice of fragmentation enzyme imposes constraints that shape which features are most readily obs...

Transcriptomic insights into exogenous fatty acid-enhanced halotolerance in Zygosaccharomyces rouxii.

Exogenous C16:1 elicited a focused transcriptional adjustment rather than broad transcriptome-wide reprogramming in salt-stressed Z. rouxii, indicating that peroxisome-linked lipid processes and redox regulation were candidate mechanisms underlying fatty-acid-associated halotolerance and provided targets for improving...