Sarcopenia and type 2 diabetes mellitus (T2DM) share common pathophysiological mechanisms and are mutually aggravating, which makes the search for pathogenetically justified treatment approaches an urgent task. The present study examined changes in myokine status and metabolic parameters in patients with T2DM and sarco...
Azizbek Izatillayev· SOUTH ARAL SEA MEDICAL JOURN...· 0 citations
Applying the 240-root E8 lattice with phi-scaled 132 Hz coupling to the geometric constraints of helical stacking reveals that only a 17-layer phyllotaxis configuration achieves simultaneous E8 root alignment across all three orthogonal 80-root families. Beyond 17 layers, the helical pitch ratio drifts past the phi-tol...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
Scientific design requires reasoning in scientific spaces that represent the objects being designed. Building on Scinetics' Chain of Science Tokens, we present chain-of-structures (COS) as a concrete protein-design case study that connects reasoning and generation through explicit structural states. In this technical r...
Qingran Cai, Mingyang Xu, Jiaxian Yan et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Friedreich ataxia (FRDA) is an inherited multisystem disorder caused by a GAA repeat expansion in the FXN gene and consequent frataxin deficiency, causing progressive neurodegeneration and heart disease. Clinical studies have documented autonomic dysfunction in FRDA, including elevated resting heart rate, raised plasma...
Shiang Yong Lim, Jarmon Lees, H Zhang et al.· bioRxiv (Cold Spring Harbor...· 0 citations
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Data deposit accompanying 'Grading surface-protein imputation from single-cell transcriptomes' (Bioinformatics, 2026). It contains the five CITE-seq datasets used in the paper after gene and antibody-panel harmonisation (CBMC, GSE100866; PBMC 3' and 5', GSE164378; COVID-19 PBMC, GSE155673; bone marrow, GSE128639), the...
A single nucleotide polymorphism (rs2304297) in the 3' untranslated region (UTR) of CHRNA6, encoding the alpha6 nicotinic acetylcholine receptor subunit, is associated with adolescent smoking behavior. Humanized rats carrying the 'C' or 'G' allele show sex- and genotype-dependent responses to adolescent nicotine, yet t...
Yasamin Hajy Heydary, Emily M. Castro, Kaylie S. Gurholt et al.· bioRxiv (Cold Spring Harbor...· 0 citations
ABSTRACT Fluorescent proteins (FPs) are widely used in biological imaging, yet their limited programmability restricts adaptability for advanced nanoscale applications. Synthetic molecular containers offer designable cavities but struggle to simultaneously achieve large dimensions, biocompatible interfaces, and precise...
Galactose oxidases (GalOxs) are copper-radical enzymes that selectively oxidize primary alcohols, yet the structure–function determinants governing their catalytic efficiency and substrate scope remain incompletely understood, particularly in bacterial enzymes. Here, we combine biochemical and structural characteriza...
André Taborda, Tomás Frazão, Tiago H. Lopes et al.· Chem & Bio Engineering· 0 citations
FINDING: Icosahedral symmetry dominates viral capsid architecture, with quasi-equivalence theory explaining how identical protein subunits assemble into 60n-valence shells. | MATH: Icosahedral group I_h (order 120); capsid triangulation number T = h² + hk + k² (Caspar-Klug), yielding T = 1, 3, 4, 7, 9, 13, 16, 19, 21.....
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
ULTRAMETRIC ANALYSIS OF PROTEIN ENERGY LANDSCAPES BASED ON KINETIC METRICS AND MARKOV STATE MODELS (MSM) Author: A. P. Zubarev Version: 1.12 (Fixed architecture: MD is launched only MAIN_NUM_SAMPLES times, files are saved with suffixes, ALPHA_ANALYSIS uses prepared trajectories. Table output is unconditional, added alp...
apzubarev· Zenodo (CERN European Organi...· 0 citations
Lysophosphatidic acid (LPA) and the enzyme that generates it, autotaxin, have been shown to play a role in fibrosis in the trabecular meshwork in glaucoma, contributing to increased intraocular pressure. We wished to investigate the role of LPA and autotaxin in fibrosis of the lamina cribrosa (LC) of the optic nerve he...
Amy O’Regan, Mustapha Irnaten, Sarah Eivers et al.· Scientific Reports· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
