The present study highlights the importance of unusual statine residues in the development of minimal peptidomimetic hydrogelators and expanding the secondary structural diversity for the rational design of short peptidomimetic hydrogelators.
Archit Kadu, Sourav Sen, Rohit Y. Sathe et al.· Journal of materials chemist...· 0 citations
By carefully controlling ionic strength, and/or by mutating interface residues by design, it is possible to make high quality, highly immunogenic VLPs directly from unpurified bacterial lysate, without requiring the use of a disassembly/reassembly step.
X. Yuan, K. Nand, J. C. Patel et al.· Protein Science· 0 citations
A targeted exosomal strategy for modulation of eNSCs is established and its potential for promoting endogenous repair following SCI is highlighted to highlight its potential for promoting endogenous repair following SCI.
Qing Liu, Ang Lv, Ya-Bin Lin et al.· Materials Today Bio· 0 citations
The emergence of antibiotic-resistant pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA), represents a major public health threat, with limited treatment options. Bacteriophage-derived endolysins and their engineered chimeric derivatives have attracted attention as alternative antibacterial agen...
Sarvenaz Janbaz, Amir Savardashtaki, Marziyeh Asadi et al.· Biotechnology and applied bi...· 0 citations
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Comparison of macromolecular structural models requires similarity measures that remain informative for complexes, interfaces, and binding sites. Widely used scores emphasize global superposition or distance deviations and are not designed primarily for direct assessment of contact patterns. A fast and flexi...
ABSTRACT Heterologous expression—the expression of genes from one organism into another—is an important approach to produce value-added chemicals such as proteins and metabolites. The main challenge, however, is achieving high production yields that are commercially viable. Approaches used to improve productivity rely...
Adjo E. Kadjo, Galen Ptacek, Barbara I. Adaikpoh et al.· Applied and Environmental Mi...· 0 citations
Abstract Proteins evolve allosteric mechanisms through sequence variation while preserving a conserved structural fold. How these substitutions reshape the protein's conformational landscape to drive functional diversification remains poorly understood. Members of the cAMP receptor protein family (CRP), a ubiquitous ba...
Sanuja Mohanaraj, Miray Samuel, Eva Siminiceanu et al.· Protein Science· 0 citations
MOTIVATION
A central challenge in protein-ligand modelling is to predict not only the presence of an interaction, but also the correct ligand identity, binding-site location, and biologically relevant bound conformation. While recent deep learning approaches such as AlphaFold3 and Boltz-2 have demonstrated impressive a...
Recep Adiyaman, L. McGuffin· Bioinformatics· 0 citations
Ion-pairs are central charged motifs that control the biological function of several proteins. Yet, the physical principles linked to the formation of ion-pairs during protein folding remain poorly understood. Here, we show that buried ion-pairs of de novo-designed helical bundle proteins reshape the folding pathways b...
Jobst Liebau, Grant Kemp, Dirk Auman et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Purpose. To determine which proposed keratoconus (KC) mechanisms carry its genetic susceptibility and how it relates to corneal structure, and which describe its corneal tissue. Methods. Six mechanism modules and two attribution sets (transforming growth factor-β [TGF-β] and canonical type-2 atopy) were tested for enri...
涵宇 蒋, Fei Gao, Wei Zhang et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Introduction. Polycyclic aromatic hydrocarbon (PAH) toxicology has been primarily defined by host metabolic bioactivation to reactive intermediates. Yet ingested PAHs and biliary-delivered metabolites also enter the intestinal lumen, where they encounter the gut microbiota, an additional but understudied metabolic comp...
Chinenye P. Nwike, Oluwatosin P. Shittu, Madison E Andrews et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Data and code for a cutoff-controlled benchmark of 26 cysteine-targeted covalent protein–ligand complexes, all X-ray structures at 1.1–1.82 Å released after the Chai-1 training cutoff of 30 September 2021. Three predictors are scored on identical inputs: co-folding (Chai-1 v0.6.1), blind docking (smina, Vina scoring) a...
Karrar Al‐Ameed· Zenodo (CERN European Organi...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
