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340 papers
These highly powered, sedation-contextualized RI provide a definitive, species-specific diagnostic framework that will significantly enhance veterinary care, colony management, and the interpretation of translational research utilizing A. nancymaae.
Differential serum peptide expression in AR patients treated with BJK remedy compared to loratadine compared to loratadine is investigated using MALDI-TOF MS and LC-MS/MS to elucidate the mechanisms of BJK remedy and loratadine in treatment, supporting the further development of targeted therapies and biomarkers.
MCTH (Monte Carlo Tree Hallucination), an inference-only framework that casts all-atom sequence-structure co-design as uncertainty-aware planning over hallucinated states from pretrained folding and inverse-folding models, with optional biophysical control within the same decision loop is introduced.
HRBD demonstrated potent and broad-spectrum inhibition against Pangolin-CoV, SARS-CoV, SARS-CoV, SARS-CoV-2, and its variants, lowering the half-maximal inhibitory concentration (IC50) by approximately 1000-fold compared to the monomeric RBD.
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Results demonstrated that the chimeric vaccine provides preliminary protection against a local B2 UPEC isolate, and modulating gut microbiota via faecal transplantation markedly enhances the immunogenicity and protective efficacy of vaccination, suggesting its adjuvanticity.
In situ atomic force microscopy is used to reveal the two-dimensional crystallization dynamics of streptavidin on muscovite mica with single-molecule resolution, establishing a paradigm of domain coarsening in biomolecular epitaxy, providing a solid foundation for the rational design of functional bio-nano interfaces.
ProteinReasoner is developed, a multimodal generative protein foundation model that sequentially connects amino acid sequence, evolutionary constraints and three-dimensional structure within a shared autoregressive architecture and suggests a general route towards reasoning across interdependent representations in other scientific domains.
Porous silicon (PSi) biosensors offer significant potential for point-of-care diagnostics, yet their analytical performance is constrained by slow analyte diffusion into the porous matrix. To address this issue, we developed a lab-on-a-chip (LOC) device that combines a PSi immunosensor with a surface acoustic wave (SAW)-driven mixer, housed in a 3D-printed microfluidic flow cell. The platform was evaluated for the optical detection of lactoferrin (LF), a protein biomarker relevant to inflammatory bowel disease and chronic pancreatitis. Acoustic streaming generated by the SAW mixer enhanced convective mixing at the microscale and increased mass transfer of the target analyte towards the sensor surface. SAW-driven mixing achieved a 3-fold increase in the signal-to-noise ratio and a 5-fold reduction in the limit of detection compared to unmixed conditions, advancing the analytical range towards clinically significant concentrations.
This strategy provides a rapid, selective, and scalable way to introduce aromatic PTMs, producing homogeneous protein libraries essential for mechanistic studies, biomarker development, and exploring the therapeutic potential of targeting aSyn-phosphorylation for PD and related disorders.
Results identify Cryaa as a critical regulator of ER stress and demonstrate that its reduction promotes UPR activation and subsequent photoreceptor apoptosis in the rd9 model, revealing a key role for Cryaa in XLRP pathology and may provide a novel therapeutic perspective for this disease.
ABSTRACT Microplastics (MPs) accumulation in ecosystem and human organs poses urgent environmental and health risks, yet few enzymes efficiently degrade polyethylene terephthalate (PET) under physiological conditions. We leveraged deep learning to mine unexplored sequence space across 246 million proteins, discovering AhPETase, an evolutionarily distinct hydrolase with low homology (<50% sequence identity) to known PET‐degrading enzymes. This noncanonical biocatalyst efficiently depolymerizes PET at 37°C, outperforming all typical PETases and achieving a 7.76‐fold enhancement over IsPETase, one of the most representative mesophilic PETases. Additionally, engineered variant AhPETaseM1 retains functional activity for over 20 days under physiological conditions and can degrade post‐consumer PET MPs 34‐fold faster than recombinant human‐derived enzyme MG8 (rMG8) under equal enzyme loading. Critically, it reversed PET‐induced toxicity in human lung and colon cells, establishing the first proof‐of‐concept for enzymatic MPs detoxification.
SIRT1–GAPDH signaling represents a post-translational axis linking sirtuin activity directly to glycolytic enzyme function, distinct from SIRT1's traditional transcriptional roles and serving as a viable molecular checkpoint in microglial immunometabolism.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease