A DDP-doped black phosphorus (BP) nanomedicine protected by polydopamine coating that synergistically delivered DDP and piezoelectric BP to precisely disrupt resistance homeostasis and thereby reverse DDP resistance is established.
Yijie Fan, Jingning Zhang, Cong Liu et al.· Advances in Materials· 0 citations
The most potent strain, Bacillus paralicheniformis UB08 (TISTR 10842), displayed an extraordinary nominal Pb tolerance, with a minimum bactericidal concentration exceeding 9,000 ppm, and alginate bead encapsulation enables rapid and complete Pb removal, offering a promising solution for heavy metal treatment based on physical adsorption and potential biological synergies.
Kaninnut Sangkhum, T. Panich-pat, P. Nimnoi et al.· PeerJ· 0 citations
The proposed multi-epitope vaccine shows promising immunological and structural properties, supporting its potential against S. typhimurium, pending experimental validation.
Mohammed Naveez Valathoor, A. P. Rajan· Scientific Reports· 0 citations
Pockets from a protein language model at locations where geometry finds no concavity improves single-structure recovery by 8.5% (95% CI +4.0 to +13.6) on test-fold data, and lets a five-conformer ensemble match a twenty-conformer one at a third of the wall clock.
Clayton W. Moore· bioRxiv· 0 citations
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Data reveal for the first time that CIGB-300 treatment is able to induce extracellular HMGB-1 release in vitro and in vivo which could be indicative of ICD induction in some kinds of tumors; furthermore, the induction of extracellular HMGB-1 alarmin as a putative CIGB-300 response biomarker merits further investigation.
Daylen Aguilar-Noriega, Ying Yi, Jamilet Miranda et al.· Kinases and Phosphatases· 0 citations
An evolved hierarchy of paralog-specific JDP couplings that dynamically rewires the Hsp70 network from active repair to protection during stress is revealed, revealing an evolved hierarchy of paralog-specific JDP couplings that dynamically rewires the Hsp70 network from active repair to protection during stress.
Roni Suhler, Lars J W van Beurden, Merav D. Shmueli et al.· Proceedings of the National...· 0 citations
It is demonstrated that conformationally distinct tau polymorphs associate with disease-specific interaction networks across Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies, providing molecular insight into tauopathy heterogeneity.
These highly powered, sedation-contextualized RI provide a definitive, species-specific diagnostic framework that will significantly enhance veterinary care, colony management, and the interpretation of translational research utilizing A. nancymaae.
Carlos Gaspar, M. Nieto, N. Espinoza et al.· Scientific Reports· 0 citations
Differential serum peptide expression in AR patients treated with BJK remedy compared to loratadine compared to loratadine is investigated using MALDI-TOF MS and LC-MS/MS to elucidate the mechanisms of BJK remedy and loratadine in treatment, supporting the further development of targeted therapies and biomarkers.
Vilailak Tiyao, Sitthirug Roytrakul, Janthima Jaresitthikunchai et al.· International Journal of Mol...· 0 citations
MCTH (Monte Carlo Tree Hallucination), an inference-only framework that casts all-atom sequence-structure co-design as uncertainty-aware planning over hallucinated states from pretrained folding and inverse-folding models, with optional biophysical control within the same decision loop is introduced.
Xuefeng Liu, Mingxuan Cao, Xiao Luo et al.· 0 citations
HRBD demonstrated potent and broad-spectrum inhibition against Pangolin-CoV, SARS-CoV, SARS-CoV, SARS-CoV-2, and its variants, lowering the half-maximal inhibitory concentration (IC50) by approximately 1000-fold compared to the monomeric RBD.
Jintao Zou, Lingyu Su, Jiansheng Lu et al.· Antiviral Research· 0 citations
Results demonstrated that the chimeric vaccine provides preliminary protection against a local B2 UPEC isolate, and modulating gut microbiota via faecal transplantation markedly enhances the immunogenicity and protective efficacy of vaccination, suggesting its adjuvanticity.
A. T. Koro, H. Altaii· Frontiers in Immunology· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.