Category
2,220 papers
Findings identify autophagy-regulated amino acid homeostasis as a critical mechanism that sustains Foxo1 protein abundance and supports glucagon-responsive hepatic metabolic adaptation during fasting.
The results provide the first integrated characterization of nsLTPs in Cereus, supporting a gate-modulation hypothesis in which structural variation concentrated at tunnel entrances may contribute to functional diversification while preserving the conserved nsLTP fold (four-helix scaffold).
The mechanisms of protein folding, misfolding, aggregation, and prion-like propagation in major neurodegenerative proteinopathies, including amyloid-beta and tau in Alzheimer's disease, alpha-synuclein in synucleinopathies, TDP-43 and FUS in ALS/FTLD, polyglutamine-expanded proteins, prion proteins, and rare hereditary...
AIMS Aeromonas hydrophila is a zoonotic pathogen, and its prevalence of drug resistance underscores the urgency of elucidating alternative bactericidal strategies. This study employed the oxytetracycline-resistant strain OTC-A01 to investigate the bactericidal mechanism of ε-polylysine (ε-PL). METHODS AND RESULTS Wit...
Reach audiences
Advertise in front of researchers, engineers, and readers.
BACKGROUND Moulting is a crucial process in the growth and development of insects and is also a key focus in the development of insecticides. Cyromazine, a moulting disruptor, is widely used to control dipteran pests, yet its mechanism of action and the genetic basis of resistance remain unclear. This study aimed to sy...
Inspired by the protein–vitamin interactions reported in the literature, the present work explored three vitamin B complexes, viz., vitamins B1, B6 and B12, and separately investigated their amyloid inhibitory activities on insulin, showing the considerable amyloid inhibitory activity of thiamine on insulin aggregation...
Salivary neuropeptide Y, interleukin-18 and malondialdehyde are independently associated with periodontitis, whereas salivary tight junction proteins track disease severity without independent association, consistent with downstream barrier injury.
A colorimetric/chemiluminescent vertical flow immunoassay (VFI) for Brucellosis was developed using glutathione-protected cobalt–gold nanoclusters conjugated with staphylococcal protein A (GSH@Co–AuNCs–SPA) as multifunctional catalytic immunoprobes. The nanocluster probe integrates antibody recognition with peroxidase-...
This work developed PanRes, a curated resistance database of 11,717 genes integrating acquired and latent determinants of antibiotic, biocide, and metal resistance within a unified ontology, and predicted representative protein structures and clustered them by structural similarity.
Alpha/Beta hydrolase fold-containing protein; Leishmania infantum (strain JPCM5)
Abstrak Latar belakang. Sindroma Down (SD) adalah aneuploidi autosomal viabel tersering pada manusia dan penyebab genetik utama disabilitas intelektual. Sekitar 95% kasus berupa trisomi 21 bebas (47,XX/XY,+21), yang berakar pada satu peristiwa sitologis: kegagalan pemisahan kromosom 21 saat gametogenesis atau pembelaha...
Collagen, the most abundant protein in the extracellular matrix of mammalian cells, is a key biomaterial in various biotechnological and therapeutic applications, such as tissue engineering and regeneration, cosmetics, and cultivated meat. Despite the increasing demand for culture-based collagen, it is still mainly p...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
