The Sigma-1 receptor (S1R) is a ligand-regulated membrane protein whose pathogenic variants are associated with motor-neuron and neurodegenerative disorders, yet its ligand conformational selectivity and receptor organization remain incompletely understood. We systematically characterized 35 pathogenic or likely pathog...
Nikola Mitović, Nina Japundžić‐Žigon, Marija Stanojević et al.· Zenodo (CERN European Organi...· 0 citations
Colostrum, first milk produced by mammalians after parturition, is a biologically rich and complex fluid, referred to as “liquid gold” due to its exceptional nutritional and immunological properties. Among the bioactive molecules, proteins play critical roles in neonatal development and immune protection, notably due...
Isalyne Drewek, Blandine Chazarin, R. Wattiez· Journal of Agricultural and...· 0 citations
Fibroblast activation protein (FAP) is a promising pan-tumor target for theranostics, but current FAP-targeted radioligands are limited by insufficient tumor retention and suboptimal therapeutic doses. To address these challenges, we developed a novel LARM platform and synthesized the FAPI dimer TH2103-100. The radioch...
Fan Jia, Hui-Hui You, Xin-Ping Li et al.· Advanced Healthcare Material...· 0 citations
Force spectroscopy enables direct investigation of the interplay between free energy and transition kinetics in proteins and nucleic acids. However, multi-domain proteins often display multiple intermediate structures with diverse stabilities and kinetics, making equilibrium conditions difficult to achieve and out-of-e...
C. A. Quintana-Cataño, Andreas Hartmann, M. Schlierf· bioRxiv· 0 citations
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Early risk stratification in upper gastrointestinal bleeding (UGIB) is essential for emergency department (ED) triage, treatment planning, and mortality reduction. Although conventional clinical scores are widely used, they may not fully capture complex nonlinear interactions among physiological, laboratory, and comorb...
Duygu Sıddıkoğlu, Murat Daş, Ece Ünal Çetin et al.· BMC Medical Informatics and...· 0 citations
Neurodegenerative proteinopathies are defined by distinct proteins whose folding, trafficking and clearance depend on shared proteostasis machinery. Whether these disorders engage common components or only common processes has been unresolved. We mapped 16 disease proteins from 12 disorders onto a fixed 990-protein pro...
Bhuvaneshwar Yarlagadda, Vijay Kumar· bioRxiv (Cold Spring Harbor...· 0 citations
Volume C of the Ontology-First N.E.A. Series. Complex systems, topological value, and the enthalpy bank. The physical mainline of the Ontology-First N.E.A. Series derives the entire universe — spacetime, matter, forces, particles, atoms, cosmology, and the observer — from a single logical primitive operating under the...
Yu Zhang· Zenodo (CERN European Organi...· 0 citations
Protein engineering has become an increasingly interdisciplinary field, integrating molecular biology, structural biology, biophysics, computational modeling, and artificial intelligence to modify protein structure, stability, dynamics, molecular recognition, and catalytic activity. This systematic review examines th...
M. Z. T. de Lima, Gustavo Foltran Umbehaun, A. Tomazini· Biophysical Reviews· 0 citations
Estrogen’s broad trophic effects on anterior pituitary function are not fully understood. The compound 4-vinyl cyclohexene diepoxide (VCD) induces early ovarian failure and reduced E2 production, which may differentially affect anterior pituitary cells. We recently identified transcriptomic changes in pituitary gon...
Tiffany K. Miles, Angela K. Odle, Ashley K. Herdman et al.· Frontiers in Endocrinology· 0 citations
ELMS (Evidence-based LLM-guided Monte Carlo Search), an evaluator-in-the-loop search framework for motif scaffolding that turns such evaluator feedback into targeted design actions, is introduced.
Hao-Tian Hu, Oguzhan Gungordo, Siheng Xiong et al.· 0 citations
It is demonstrated that PDI(a)-mediated cis-fusion enables high-yield production of structurally native-like and functionally competent HSA in the bacterial cytosol and provides a practical platform for producing complex disulfide-rich proteins in E. coli.
R. Urade, Yuki Yamaguchi, K. Morishima et al.· Journal of Bioscience and Bi...· 0 citations
Abstract Rapid and scalable protein binder discovery platforms are essential for accelerating therapeutic and diagnostic development. Click display is a cell-free protein display technology that covalently links nascent proteins to their encoding cDNA in a one-pot reaction within 2 h, enabling rapid in vitro selection....
Joshua D. Bryant, Yu Zeng, Monisha Yerram et al.· Protein engineering, design...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
