This study demonstrates that ertapenem exhibits potent antibacterial activity against S. aureus and is a potential inhibitor of biofilm formation, and implicates a novel aspect of ertapenem’s activity connected to the disruption of purine biosynthesis in S. aureus through targeted downregulation of FGAM synthase.
This study aimed to clarify the association between longitudinal adalimumab concentrations, anti-adalimumab antibodies (AAA) levels, and clinical response in Chinese patients with ankylosing spondylitis (AS).
A prospective multi-center, observational cohort study of AS patients receiving adalimumab therapy w...
Xiao-Liang Ding, Ling Xue, Ming-Jun Wang et al.· Frontiers in Immunology· 0 citations
Guided bone regeneration (GBR) is a widely used clinical strategy to separate fast-proliferating epithelium from osteogenic tissue, thereby facilitating alveolar bone defect repair. In this study, a bilayered membrane was engineered by depositing coaxial electrospun Bone Morphogenetic Protein 2 (BMP2)/gelatin core-γ-po...
Yi-Tao Chang, Chuan-Ching Lai, Ying-Tong Chen et al.· International Journal of Bio...· 0 citations
Protein-templated synthesis is thus an instance of information-field self-organization in which a fixed rule set in constraint space drives real-space data toward a unique stationary occupation distribution, a principle formally analogous to those previously validated in DNA sequencing by hybridization and RNA inverse...
Kai Huang, Hong-Kui Liu, Zi-Wei Huang· Bio Systems· 0 citations
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It is demonstrated that synonymous recoding can reshape proteostasis and activity, emphasizing the need for comprehensive evaluation of engineered therapeutic genes beyond yield.
Katarzyna I. Jankowska, U. Katneni, Brian C. Lin et al.· Trends in Biotechnology· 0 citations
A series of novel semisynthetic indole-fused taraxerone derivatives (2a-2f) were synthesised from taraxerone isolated from Rhizophora stylosa Griff. and characterised by 1H NMR,13C NMR, and HRMS analyses. Incorporation of the pharmacologically important indole moiety was aimed at enhancing protein-ligand interactions a...
Pathogenic variants in the potassium channel tetramerization domain-containing 1 (KCTD1) gene cause scalp-ear-nipple syndrome (SENS), a rare autosomal dominant developmental disorder. Although the recurrent p.Gly62Asp variant has been previously reported, its genotype-phenotype correlation and structural pathogenic mec...
Yu Zhang, Qi-Feng Wu, Bao-Fu Yu et al.· The Journal of craniofacial...· 0 citations
The results suggest that high protein intake in P. ornatus does not increase catabolism of dietary protein but stimulates protein synthesis leading to reduced protein turnover and more energy efficient growth, demonstrating the importance of whole-body protein turnover to nutritional physiology and bioenergetics for op...
Trystan B. Sanders, M. B. Codabaccus, Andrea Williamson et al.· Journal of Experimental Biol...· 0 citations
OBJECTIVE
Pregnancy produces physiologic adaptations that may affect laryngeal tissues, respiratory support for phonation, and voice quality. We performed a scoping review exploring the influence of pregnancy on voice and laryngeal outcomes.
DATA SOURCES
PubMed, CINAHL, and Web of Science.
REVIEW METHODS
A scoping...
John M. Boyd, Jack T. Williams, R. McGowan et al.· The Laryngoscope· 0 citations
The symbiotic skin bacterium Staphylococcus epidermidis moisturizes human skin, contributes to protection against external pathogens, and supports innate immune stimulation. However, the interaction between collagen, a major skin protein, and S. epidermidis remains insufficiently explored. In this study, biofilm develo...
It is demonstrated that CID systems can be used as building blocks for higher-order ligand-controlled protein systems and established a generalisable strategy for harnessing the affinity gains of intramolecular CID systems to create gain-of-signal assays for small molecules and ions.
Zhen-Ling Cui, Zhong Guo, Y. Liew et al.· Angewandte Chemie· 0 citations
It is demonstrated that repeated environmental heat stress induces coordinated neuroendocrine, vascular, immune, and metabolic adaptations characterized by activation of heat shock pathways, immune remodeling, and endothelial activation that precede cardiovascular dysfunction.
Hibah Husain, Samantha A. McFall, M. Malovichko et al.· The FASEB Journal· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
