Statins suppress colon tumors by inhibiting KRAS condensates.
Medicine
Abstract
The unclear regulatory and transport mechanisms of Kirsten rat sarcoma viral oncogene homolog (KRAS) limit a comprehensive understanding of KRAS activity and the development of inhibitors. Wang et al. reported that farnesylation-induced KRAS phase separation drives colon cancer progression and resistance to G12C inhibitors. Statins can block this process, suppress tumor growth, and reverse drug resistance.