Open access
AS160 Overexpression Protects Against β‐Cell Failure in Hyperglycemic Mice by Interacting With HSPA8 to Regulate Mitophagy
Wenli Chen
Yanting Lu
Xiang-xiang Liu
Bangrui Huang
Dao-Wei Liu
Bi-Lian He
Zhi-Ming Zhao
Qian Wang
Jixi Li
Wenyong Xiong
Medicine
TL;DR
The role of AS160 in regulating mitochondrial homeostasis and insulin secretion in pancreatic β‐cells is investigated and the underlying molecular mechanism involving its interaction with HSPA8 and activation of PINK1‐Parkin‐mediated mitophagy is elucidated.
Abstract
Insulin deficiency due to pancreatic β‐cell loss and dysfunction is a key event in the pathogenesis of T1DM and a progressive driver of T2DM. This study aims to investigate the role of AS160 in regulating mitochondrial homeostasis and insulin secretion in pancreatic β‐cells, and to elucidate the underlying molecular mechanism involving its interaction with HSPA8 and activation of PINK1‐Parkin‐mediated mitophagy.