AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
PUM2 expression increases upon aging and this facilitates the capture/trapping of Mff mRNA, either alone or in association with other RNA-binding proteins (RBPs) in Ribonucleoprotein particles (RNP).
Using proximity labeling, a comprehensive interactome map of the RBP ZFP36L1 is presented, demonstrating the versatility of interactions and their possible functioning during T-cell activation.
Itchy E3 ubiquitin‐protein ligase modulates mitochondria, and thrombospondin 1 positively regulates muscle atrophy, but their roles in muscle atrophy are unclear.
PZL-26 targets LONP1 with nanomolar potency and on-target cellular activity, revealing OXPHOS and mitochondrial gene expression as key survival dependencies.
It is demonstrated that allosteric modulation of the mitochondrial protein Miro1 can selectively reprogram mitochondrial stress signaling and can produce distinct responses in disease-relevant cell types, despite acting within a broadly conserved stress pathway.
The p97-Ufd1-Npl4 complex targets ubiquitylated RAD21 to extract a subpopulation of cohesion specifically in S-phase to facilitate DNA replication and suppress replication-associated DNA damage.
This work identifies circFut8—a conserved exonic circRNA originating from FUT8 gene exon 3—as a bc tumor suppressor, which is significantly downregulated in bc tissues and cell lines, correlating with advanced tumor grade and invasion.
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