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Intrinsic flexibility of Type VII secretion central pore is required for substrate translocation

Christin Ritter Kathrine S. H. Beckham Grzegorz Chojnowski E. Mullapudi Frank Stein M. Rettel Mikhail M. Savitski Matthias Wilmanns

Jul 2026 · bioRxiv · 0 citations · 10 references

Biology

TL;DR

The functional roles of several central pore-forming residues in mediating secretion are probed and their crucial role in ESX-5 substrate translocation efficiency is demonstrated and shown to be general valid for these systems.

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