Acrylamide-associated gastric cancer progression involves RRM2-related nucleotide metabolic dysregulation and immune evasion

Abstract

Highlights • RRM2 identified as acrylamide-associated hub gene in gastric cancer.• Multi-cohort integration reveals nucleotide metabolism dysregulation.• Machine learning prognostic model stratifies GC risk groups.• Single-cell analysis uncovers immune evasion signaling networks.• Experimental validation confirms RRM2 oncogenic roles in GC.