Jul 2026· Current Medical Science· Vol 46, pp. 926 - 945· 0 citations· 168 references
Medicine
TL;DR
An overview of the PLC as a major determinant of tumor immune escape and a potential therapy target is provided and existing or evolving therapeutic approaches to recover/reprogram PLC functions are explored.
A novel method is presented for the expression in eukaryotic cells of secreted peptide exchange–competent class I MHC proteins in their native conformation and it is demonstrated that tetramers produced in this way are equivalent to conventionally produced tetramers for T-cell staining.
V. Ramachandiran, J. Shires, Richard A. Willis et al.· Journal of Immunology· 0 citations
A glycan-dependent chaperone network is defined, finely tuned by a combination of low-micromolar interactions between the constituents, that ensures efficient MHC-I maturation and illustrates fundamental principles of ER protein quality control.
Tim J. Heinke, Amin Fahim, Niko Popovic et al.· EMBO Journal· 0 citations
The main mechanisms of antigen acquisition, endocytic/lysosomal factors controlling MHCII-restricted processing and presentation, and evidence linking lysosomal dysfunction to autoimmunity are explored.
Gabriele Sergio Colangelo, Kyra J Cowan, Federico Riccardi Sirtori et al.· Journal of Immunology· 0 citations
A unified structure-energy-dynamics model explaining how Post-translational modifications function as atomic-level chemical switches in antigen presentation is established, establishing a unified structure-energy-dynamics model explaining how PTMs function as atomic-level chemical switches in antigen presentation.
This review describes the development of pathway-centered mechanistic synthesis across DNA and RNA virus families and further integrate innate immune antagonism, endoplasmic reticulum stress, antigen-presentation competence, cross-presentation limits, and virus-shaped peptide landscapes into a unified framework for und...
Yu Ye, Ying Zhang, Haobing Nie et al.· FEMS Microbiology Reviews· 0 citations
HLA-Shuttle restores antigen presentation in immunologically cold tumor cells, facilitating identification of TAAs with favorable therapeutic potential and identifying multiple novel tumor associated antigens (TAAs) from both known and novel cancer immunotherapy targets.
Daniel Hwang, Molly C. Erdman, Santosh Adhikari et al.· Journal of Immunology· 0 citations
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