Dalberoside reveals the outer membrane interface as a chemically addressable regulator of bacterial surface attachment, and inhibits adhesion by non-disruptive remodeling of the Gram-negative outer membrane interface.
An electron cryomicroscopy structure of the 60 kDa CdrA adhesive N-terminus is reported, which combined with electron cryotomography of focused-ion beam milled specimens, allows for a complete in situ model of the native adhesin and reveals a small adhesive domain (called ADEPT) at the distal tip of CdrA that is nearly...
Olivia E. R. Smith, Camila M. Clemente, Antonina Andreeva et al.· bioRxiv· 0 citations
Results indicate that MAP-AMP-immobilized surfaces provide a versatile, biocompatible, and resistance-independent strategy for preventing biofilm formation through charge-mediated hydration, offering broad potential for biomedical device coatings and antifouling applications.
Seong Hwan Kim, Je Seon Park, Dong Yun Kim et al.· International Journal of Bio...· 0 citations
Results show that HsbA proteins in Mucor lusitanicus function as regulators that couple fungal surface remodeling with developmental transitions, thereby coordinating environmental adaptation and host–pathogen interactions.
Anna Molnár, Amanda Grace Vaz, M. Homa et al.· Frontiers in Cellular and In...· 0 citations
A fluorescence-based labeling approach using fluorescent D-amino acids (FDAAs) to simultaneously track peptidoglycan biosynthesis and the localization of FadA in F. nucleatum is presented, providing a versatile platform for investigating the dynamic interplay between virulence factor localization and cell envelope remo...
Timmie A. Britton, B. Sánchez, Asis K. Das et al.· Methods in molecular biology· 0 citations
The structure reveals for the first time the interaction between a biofilm exopolysaccharide and matrix protein, as well as insights into conformational changes of exopolysaccharide induced by this binding, and provides a generalizable approach for studying the biophysical and biochemical properties of carbohydrate-dep...
Alex Hinbest, Hyerim Bianca Nam, E. Liszczyk et al.· bioRxiv· 0 citations
Outdoor membrane stiffness is revealed as a previously unrecognized physical basis of multidrug tolerance and modulating bacterial envelope mechanics may provide new opportunities for antimicrobial intervention, suggesting that modulating bacterial envelope mechanics may provide new opportunities for antimicrobial inte...
Nan Xiao, Bo Zheng, Jia-Feng Liu· bioRxiv· 0 citations
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