This review coalesces current knowledge on the abundance, mutational effects, and functional insights of lncRNAs in Drosophila testis and brain, highlighting their value as a model for deciphering conserved lncRNA biology and its implications for human reproductive health.
This chapter explores the biomedical significance of ceRNAs, highlighting their role in modulating gene expression and their potential implications in disease, and summarizes available tools, resources, and practical examples for studying lncRNA-miRNA interactions to aid researchers in navigating this sophisticated reg...
Francesco Orilio, R. Brancaccio, Francesco Verona et al.· Methods in molecular biology· 0 citations
Findings identify inherited intergenic lncRNAs as enhancer-associated regulators with elncRNA-like properties during early embryogenesis, indicating that these RNAs act as positive local regulators during MZT.
Dheeraj Chandra Joshi, Sauranil Guha, Nabeel Ahmed et al.· bioRxiv· 0 citations
This study systematically analyze the proximity and co-expression patterns of lncRNAs and TF-encoding genes in humans using genome-wide annotations and transcriptomic data to reveal consistent spatial associations and tissue-specific co-expression between lncRNAs and TFs.
T. Yamada, Martin Loza, I. Hatada et al.· Scientific Reports· 0 citations
This review examines how different types of ncRNAs contribute to cancer initiation, progression, and treatment resistance, and assesses their potential as diagnostic markers, prognostic factors, and therapeutic targets.
Akanksha Samuel, G. Calin· Carcinogenesis· 0 citations
It is proposed that the upregulated lncRNA ENSG00000265613 may enhance malignancy by stabilizing the RNA target ENSG00000582008 in luminal A breast cancer, particularly given its established role in oncogenesis.
C. Guda, Sankarasubramanian Jagadesan, Avinash M. Veerappa· Methods in molecular biology· 0 citations
THOR (testis-associated highly conserved oncogenic long non-coding RNA) is a highly conserved and testis-enriched lncRNA across vertebrates that plays diverse roles in various cancers. However, its physiological function and regulatory mechanism in testes remain largely unknown. Here, we investigated the genomic locati...
Jia-Yi Zhao, Chao-Xiong Jiang, Yi-Ran Luo et al.· Biology of Reproduction· 0 citations
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