The functional necessity of ndhB-872/QED1 co-evolution in tea and tomato, elucidate the critical role of ndhB-872 editing in tomato photosynthetic homeostasis, and offer promising methods for targeted manipulation of ndhB-872 editing in crop improvement are revealed.
Meng-Yuan Zhang, Xu-Fan Liu, Yang Meng et al.· Horticulture Research· 0 citations
Introduction Myelin oligodendrocyte glycoprotein antibody-positive optic neuritis (MOG-ON) is an autoimmune inflammatory demyelinating disorder of the optic nerve that often results in severe visual impairment and recurrent attacks. Although immune dysregulation is recognized as a central feature of MOG-ON, the contrib...
Xue-Qing Cui, Jian-Nan Ding, Xu-Chu Fu et al.· Frontiers in Immunology· 0 citations
Cancer has always been a complicated disease to understand and treat since it has complex genetic factors, heterogeneity of tumors, resistance to treatment, and metastasis. The traditional treatments of chemotherapies are associated with systemic side effects, whereas targeted therapies and conventional immunotherapies...
Karmvir Kaur, Shivani Chandel, Rajveer Singh· Next Nanotechnology· 0 citations
Mengapa buku ini dibutuhkan Terapi biologis berkembang pada pertemuan biologi molekuler, imunologi, genetika, biomaterial, manufaktur, uji klinis, regulasi, dan etik. Kompleksitas ini sering menimbulkan dua kesalahan ekstrem: menolak inovasi hanya karena belum familiar, atau menerima klaim hanya karena teknologi tampak...
Rachmat Hidayat· Zenodo (CERN European Organi...· 0 citations
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The molecular mechanisms, preclinical evidence and emerging clinical data supporting CRISPR-based CCR5 disruption, including multiplex editing strategies designed to overcome viral tropism switching, and the evolving role of maraviroc beyond viral entry inhibition are examined.
ADAR-mediated A-to-I RNA editing is crucial for proper neuronal function. However, its spatial signatures in the cerebral cortex remain largely unexplored. To address this, we developed SRDRE, an analysis framework for identifying RNA editing sites in spatial transcriptomics data. By analyzing over 40 million cells acr...
This review comprehensively summarizes approaches targeting Piezo1/2, including the development of small-molecule agonists/inhibitors, gene-editing technologies, physical modulation methods, and advanced drug delivery systems, as well as their research progress and clinical prospects.
Jing-Shu Wu, Xin-Xian Meng, Cheng-Yao Han et al.· Burns & Trauma· 0 citations
PURPOSE OF REVIEW
This review surveys recent advances in artificial intelligence-guided small molecule discovery and gene therapy, with a focus on generative and foundation models, and their translational applications to ophthalmic therapeutics.
RECENT FINDINGS
A unifying theme across recent work is the shift from ar...
Ruhi Sayana, Sean K. Wang, D. Ting et al.· Current Opinion in Ophthalmo...· 0 citations
therefore move beyond merely acknowledging context dependence and instead establish testable, context-resolved frameworks for mechanistic validation and clinical translation.A major risk in current studies of m6A in autoimmune diseases is the overinterpretation of regulator expression. Altered expression of METTL3/METT...
Gene editing has emerged as a promising tool for developing climate-resilient crops, yet discussions of its adoption have focused primarily on technological performance and public acceptance, while paying less attention to the political realignments that increasingly shape agricultural innovation. The emergence o...
Gabriella Subia, Lauren Gifford· Frontiers in Sustainable Foo...· 0 citations
Overall, lysine acylation is closely associated with metabolic disturbances, hepatic inflammation, and fibrogenic processes in MASLD and is highlighted regarding the potential of lysine acylation as a biomarker and therapeutic target.
Jing-Yi Peng, Ankangxin Yan, Guang-Lei Chen et al.· Frontiers in Immunology· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
