gene editing

Emerging epigenetic therapies

Crosstalk between DNA methylation and chromatin structure

Global Cultivation, Utilization, and Consumption of Transgenic Plants Globally

The growing global demand for food, integrated with the development of genetic engineering technologies aimed at generating beneficial genetically modified (GM) crops, has enhanced the production of GM crops and raised their awareness in the food market. Many countries or regions require risk assessment protocols for G...

A Whole-transcriptome Sequencing Dataset from the longissimus dorsi Muscle of CD163/pAPN Double-knockout Pigs

Gene editing holds promise for improving disease resistance in livestock. We previously generated CD163/pAPN double-knockout (DKO) pigs that exhibit resistance to multiple viruses while maintaining normal production traits. However, broader application of gene-edited animals requires careful evaluation of potential mol...

Dynamic expression of estrogen receptor subtypes during brain development and their mechanistic roles in anesthetic-induced cognitive dysfunction: a review

Estrogen receptor subtypes exhibit dynamic spatiotemporal differences across stages of brain development, forming a molecular basis for the regulation of neurogenesis, synaptic plasticity, and cognitive function. Commonly used general anesthetics can disrupt endogenous estrogen signaling pathways in the brain and con...

STEM CELLS IN ORAL AND MAXILLOFACIAL SURGERY: CURRENT CONCEPTS AND RECENT ADVANCES

Stem cells are characterized by self-renewal and the capacity to differentiate into specialized cell types, making them important candidates for tissue engineering and regenerative medicine. This narrative review summarizes the classification, sources, biological characteristics, storage and transport considerations, m...

Application of the Transgenic Approach in the Plant System

Transgenic technology has emerged as one of the most powerful and innovative tools in modern agriculture, offering effective solutions to the growing challenges of population expansion, climate change, land degradation, and increasing biotic and abiotic stresses. The ability to introduce precise and beneficial genes fr...

基于生物特征唯一标识与联盟区块链的器官移植全链路可信溯源体系研究 Research on Full-Link Trustworthy Traceability System for Organ Transplantation Based on Unique Biological Identification and Consortium Blockchain

作者:郭洋洋Author: Guo YangyangORCID:0009-0006-6669-1790Contact email:gyy-goes@foxmail.comPublication Type: PreprintSubmission Date: October 9, 2026Version: v1.0 Final Bilingual EditionPreprint DOI: 10.5281/zenodo.23264638Open Access License: CC BY 4.0 Abstract / 摘要 English:Organ transplantation is a core therapeutic...

Novel Treatments of Cancer

Cancer treatments have evolved over the years and have given hope to cancer patients by extending and improving their quality of life. The field is moving towards more personalized treatments with less toxicity. One of the areas that has been rapidly expanding in the recent years involves next-generation immunotherapie...

CRISPR editing of TERMINAL FLOWER 1 recapitulates perpetual flowering in strawberry, mimicking repression by the PERPETUAL FLOWERING locus.

Light is shed on the mechanism of flowering regulation by the PF locus and biotechnological approaches to achieve extended flowering in any strawberry cultivar are expanded.

What's New Is Old: "Cultural Lag" and Governance of Risk in the Life Sciences.

As advancement in the life sciences quickens, management of risks remains reactive, creating problematic delays in risk mitigation and difficulties for development of a holistic risk governance strategy. A reactive posture for addressing risk undermines biosecurity and contributes to public distrust in science. This pr...

[Genetic therapies for Stargardt disease].

The diversity of these approaches takes account of the broad spectrum of diseases that ranges from a disease limited to the macula to a generalized rod-cone dystrophy and perspectively opens up individualized treatment strategies depending on the genotype and phenotype.