Since ancient times, human societies have relied on plants not only as a source of food but also for flavors, remedies, and a variety of other purposes. Historical accounts from various civilizations such as the Egyptians, Romans, and Chinese clearly documented the diverse applications of medicinal and aromatic plants...
MATRIN3 (MATR3) is a broadly expressed nuclear RNA-binding protein. However, the mechanisms by which MATR3 maintains human cellular health remain poorly understood. In this study, we employed gene editing to model MATR3 deficiency in human induced pluripotent stem cells (iPSCs) and the HAP1 haploid cell line. To invest...
Zohirul Islam, A. Polash, Colin L. Sweeney et al.· Proceedings of the National...· 0 citations
Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system affecting approximately 3.1 million people worldwide and predominantly women. The major genetic risk factor for the disease is the Human Leukocyte Antigen (HLA) locus, while environmental and epigenetic factors...
Given the growing emphasis on the efficient application of CRISPR/Cas9 in plant genome editing, there is a need for methodologies that enhance targeted mutagenesis efficiency. In the present study, we utilized stable transgenic maize callus tissues harboring active CRISPR/Cas9 vector systems targeting either the
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B. Nagy, Aysha Jameel, G. Horváth et al.· Frontiers in Genome Editing· 0 citations
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Promoters are core cis-regulatory elements that determine gene expression levels and dynamic responses, and their quantitative engineering directly dictates the performance of synthetic biological systems such as whole-cell biosensors. However, the transcriptional output of complex inducible systems, exemplified by σ...
Yu-Xi Xu, Ming-Xuan Song, Wen-Long Xing et al.· Frontiers in Microbiology· 0 citations
Cadmium (Cd) is an emerging environmental risk factor for cognitive decline and Alzheimer’s disease, and few interventions limit its effects on the brain. Akkermansia muciniphila, a human gut commensal, is neuroprotective through mechanisms that remain unclear. Building on our finding that A. muciniphila prevented Cd-i...
Zachary Kowash, J. Lim, Andrew J. Annalora et al.· bioRxiv· 0 citations
It was found that the regulatory documentation of the Russian Federation and the EAEU lacks criteria for applying the platform approach to mRNA vaccines and gene therapy products, which hinders the accelerated introduction of innovative personalized medicinal products into clinical practice.
N. S. Pokrovsky, E. Melnikova, V. Merkulov· Biological Products. Prevent...· 0 citations
β-thalassaemia is characterised by ineffective erythropoiesis, chronic anaemia, haemolysis, and progressive iron-related and non-iron-related morbidity. Although transfusion, iron chelation, multidisciplinary care, and allogeneic haematopoietic stem-cell transplantation have substantially improved outcomes, major gaps...
K. Musallam, Sujit Sheth, Franco Locatelli et al.· The Lancet Haematology· 1 citation
Bu bölüm, kromozomların hücresel ve mikroskobik düzeyde incelenmesini konu alan sitogenetik bilim dalını ele almaktadır. Hücre döngüsü ve kromozom organizasyonundan başlanarak, karyotipleme, kromozom bantlama teknikleri (G-, Q-, R-, C-bantlama) ve floresan in situ hibridizasyon (FISH) gibi temel sitogenetik yöntemler a...
Hasan Basri İla, Rumeysa Mese· Akademisyen Kitabevi eBooks· 0 citations
Tumor-associated macrophages (TAMs) integrate multiple microenvironmental signals, including lectin-mediated recognition of tumor-associated glycans. Although several myeloid lectins have been implicated in tumor–macrophage interactions, their contributions to immunosuppressive TAM phenotypes remain poorly defined. We...
Gonçalo Trindade, M. Pinto, G. Domenici et al.· bioRxiv· 0 citations
As a powerful gene-editing tool, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system features simple construction, precise targeting, and higher editing efficiency, bringing prospects of radical cures for numerous critical illnesses at the genomic level. To date, ex v...
"Photoperiod_Editing_GH24-25_Analysis.Rmd" is an R markdown file with R script to analyze trait data from greenhouse trial."qRT-PCR_Chapter2.Rmd" is an R markdown file with R script to analyze gene expression data."Photoperiod Editing Field 2025 Analysis NatComms.Rmd" is an R markdown file with R script to analyze trai...
James Brendan Holland, Destiny Tyson· Figshare· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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