Wiskott-Aldrich syndrome (WAS) is an inborn error of immunity with a broad disease spectrum, classified into class I (late onset) or II (early onset) variants. Thrombocytopenia and small platelets are the most consistent findings among patients, difficult to treat and related to development of autoimmunity. To identify...
R. Vieira, Lia Goncalves Pinho, Tracer Yong et al.· bioRxiv· 0 citations
In the last decade, there has been an explosion in the development of in vivo germline genetic editing technologies in arthropods, first pioneered by the Receptor-Mediated Ovary Transduction of Cargo (ReMOT Control) method. While ReMOT Control and related technologies (DIPA-CRISPR and SYNCAS) have shown great utility f...
N. Nejat, Travis van Warmerdam, Jason L. Rasgon· bioRxiv· 0 citations
Postoperative recurrence remains a critical challenge in cancer management, necessitating innovative strategies to reshape the tumor microenvironment (TME) and enhance immune surveillance. This review highlights nanomedicine‐driven breakthroughs in postoperative immunotherapy, emphasizing their potential to overcome...
Li-Song Pang, Zhuo-Min Wang, Zhen-Hua Jin et al.· BMEMat· 0 citations
Correlation clustering seeks a partition of the vertex set of a given graph/network into groups of closely related, or just close enough, vertices so that elements of different groups are not close to each other. The problem has been previously modeled and studied as a graph editing problem, namely Cluster Editing , wh...
Faisal N. Abu-Khzam, Lucas Isenmann, Sergio Thoumi· Scientific Reports· 0 citations
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Three experts in the field of programmable genome engineering systems using recombinases; transposases; transposases; genome writing systems; and retrotransposons promise different avenues for therapy, but each system has unique limitations.
Alexandra Despang· Nature Biotechnology· 0 citations
Inherited mitochondrial cardiomyopathies arise from pathogenic variants affecting oxidative phosphorylation, mitochondrial DNA maintenance, cardiolipin remodeling, protein import, cofactor metabolism, and mitochondrial dynamics or proteostasis. These disorders may be cardiac-predominant or part of multisystem disease....
Chung-Lin Lee, Chih-Kuang Chuang, Ya-Hui Chang et al.· International Journal of Mol...· 0 citations
This review examines the genetic design principles and liabilities of bacteria-based therapeutics, approaches used to produce clinical and near-clinical candidates, and the emergence of programmed bacteria delivering complete gene editing systems to therapeutically relevant cells.
Ashley B. Williams, Thomas M. Groseclose, Sara A. M. Holec et al.· Genetics· 0 citations
CRISPR–Cas12a underlies powerful genome-editing and nucleic-acid detection technologies, yet its performance is limited by inefficient target engagement and low catalytic turnover, particularly at low target abundance and elevated temperatures. Here, we report a modular protein-engineering strategy to enhance Cas12a tr...
The production of cultured meat is constrained by the limited proliferation and differentiation capacity of seed cells. Here, we report that prolonged in vitro culture induces cellular senescence in bovine muscle stem cells (bMuSCs), impairing their proliferative and myogenic potential. We then examined the expression...
Long-Fei Zhang, Yuxuan Jiang, Yu Zheng et al.· Food Research International· 0 citations
Analysis code and derived result tables for a multi-cohort, in-silico study quantifying choline-glycerophospholipid reprogramming across the metabolic dysfunction-associated steatotic liver disease (MASLD) spectrum. Score definition. ChoRS is a frozen set of 158 unique genes in five non-overlapping modules: M1 Kennedy...
Analysis code and derived result tables for a multi-cohort, in-silico study quantifying choline-glycerophospholipid reprogramming across the metabolic dysfunction-associated steatotic liver disease (MASLD) spectrum. Score definition. ChoRS is a frozen set of 158 unique genes in five non-overlapping modules: M1 Kennedy...
Current knowledge of ABA signaling pathways and their roles in drought resilience in Populus is summarized, covering physiological responses, molecular regulatory networks, hormonal crosstalk, biotechnological advances, and emerging field applications.
Sajid Ali, Shakir Ullah, Mansoor Hayat et al.· Current Issues in Molecular...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
