AI-assisted scientific discovery increasingly seeks to move beyond generating plausible ideas toward reproducible, constraint-aware workflows that can support practical engineering decisions. We present MARS, a hierarchical Multi-Agent Reasoning System for knowledge-grounded material substitution under scientific and m...
Tarjei Paule Hage, Subhadeep Pal, Wei Lu et al.· 0 citations
A defined-benefit pension is only as safe as its sponsor, yet sponsor distress is under-instrumented relative to plan-side modelling. We present a transparent, reproducible early-warning pipeline built entirely on public data. A Sponsor Vulnerability Index (SVI), a gradient-boosted classifier over point-in-time SEC EDG...
Calibrated typed-decision ("System One") models return a label and a probability in a single forward pass at a small fraction of the cost of large language models (LLMs), yet their evaluation has been almost entirely English. We report a pre-registered evaluation of the commercial Jev model and the open Laya-multilingu...
Despite advancements in sub-pixel decoding, modern Human Pose Estimation (HPE) architectures remain constrained by deterministic coordinate extraction from discrete heatmaps, which systematically fails under dense occlusions and Out-of-Distribution (OoD) ambiguities. To address these limitations, we propose a post-hoc...
Santiago Reina Alguacil, Ezequiel L\'opez Rubio· 0 citations
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Training on broad, unfiltered data enables high-quality image generation, but can also teach models concepts that should not be generated; restricting the training data ensures safety, but reduces quality because examples containing unsafe concepts also provide useful knowledge that is not itself unsafe. Existing appro...
Anirudh Sundara Rajan, Krishna Kumar Singh, Richard Zhang et al.· 0 citations
Drug development is an expensive and lengthy process requiring developers to select drugs for human trials and diseases to target. Computational tools that can estimate before testing which drug-disease candidates are most likely to reach FDA approval could reduce development time and costs through early program advanc...
Positional embeddings encode the spatial position of each image patch in a Vision Transformer (ViT), allowing the model to distinguish different spatial arrangements of visual content. However, we know little about how the choice of embedding shapes a vision transformer's internal representation. In this work, we show...
Mahmoud Mannes, Nikhil Maturi, Parva Mehta et al.· 0 citations
Evaluating recommender systems before deployment requires simulators that remain realistic over long, closed-loop interaction cycles. Current LLM-based agents generally function as surface imitators that generate realistic short-term responses but fail to capture the underlying user dynamics such as fatigue, affect, an...
Chong Zhang, Qi-Jie Shen, Hai-Chao Zhang et al.· 0 citations
Unsupervised anomaly detection, which learns only from normal images, is a central task in medical image analysis and remains an open problem. Reconstruction-based methods pass an image through an encoder-decoder network trained on normal data and detect anomalies from the residual between the image and its reconstruct...
Shouhei Hanaoka, Takahiro Nakao, Atsushi Takamatsu et al.· 0 citations
The conjugate gradient (CG) method is a classical iterative solver for sparse symmetric positive definite (SPD) linear systems, but its convergence strongly depends on the spectral properties of the system matrix. Preconditioning can improve these properties; however, designing preconditioners that generalize across di...
Candidate sourcing for recruiters is best viewed as a two-stage retrieval and reranking pipeline with recall as the primary objective under a limited review budget. An upstream production retriever first returns a candidate shortlist for each job description (JD), and our goal is to rerank that shortlist so that qualif...
Zhaohua Liang, Zhilin Wang, Renjie Cao et al.· 0 citations
Zero-Shot Object Navigation (ZSON) in unknown multi-floor environments presents a significant challenge. Recent methods, mostly based on semantic value greedy waypoint selection, spatial topology-enhanced memory, and Multimodal Large Language Model (MLLM) as a decision-making framework, have led to improvements. Howeve...
Jingzhi Huang, Junkai Huang, Haoyang Yang et al.· 0 citations
A machine-learning approach called CheMeleon provides a practical way to develop new drugs or other molecules with much less detailed, expensive experimentation.
Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.
Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.
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