Building on the first collection on the topic, the second volume comprises seven original research articles, two case reports, one perspective, and one systematic review.Three research papers focus on rheumatoid arthritis (RA)-related biomarkers and inflammatory mechanisms, spanning cell death, cardiovascular complicat...
Li Zeng, Jian Liu· Frontiers in Immunology· 0 citations
ABSTRACT Fecal microbiota transplantation (FMT) carries a risk of infection. Cell-free fecal filtrate transplantation (FFT) represents a potentially safer alternative. The benefit of FFT has not been explored in alcohol-associated liver disease (ALD). We evaluated the therapeutic potential of FFT in a murine model of A...
Nishu Choudhary, Ashi Mittal, Kavita Yadav et al.· Microbiology spectrum· 0 citations
Abstract Glucagon‐like peptide‐1 (GLP‐1), secreted by enteroendocrine L cells, plays a crucial role in glucose homeostasis and appetite regulation. The identification of food‐derived bioactive compounds capable of stimulating endogenous GLP‐1 secretion has attracted increasing attention in the development of functional...
Hongdong Song, Shaoxia Ren, FU Qiuyun(傅秋云) et al.· Food biomacromolecules.· 0 citations
RNF5 is identified as a regulator of ERAD-adaptor abundance and NHK processing, while leaving the causal relationship between adaptor regulation and the RNF5-depletion phenotype to be resolved by formal rescue and epistasis studies.
Biophysical principles underlying peptide-mediated modulation of ion channels support a framework in which ion-channel modulation emerges from the coupled behavior of peptide, lipid bilayer, and membrane protein rather than from toxin binding alone.
Diego Santos Souza, Camila Dourado, Pedro V. Moraes-Santos et al.· Biophysical Reviews· 0 citations
Background Liver depression syndrome (LDS) is a core Chinese medicine (CM) syndrome implicated in the onset and progression of breast cancer, whose molecular mechanisms remain poorly understood, hindering further investigation. Methods We prospectively enrolled 146 participants and conducted transcriptomic, proteomic,...
Qianqian Guo, Jieting Chen, Geng Yang et al.· Frontiers in Immunology· 0 citations
TIR domains are found in diverse immune signaling proteins and, in several systems, function as NAD+-cleaving enzymes causing or signaling cell death. In plants, TIR domains occur as effector domains in TNL immune receptors, where they are coupled to a central STAND ATPase and a C-terminal repeat domain. Here, we ident...
Joëlle Hornebeck, Р. Б. Ибрагимов, Nicole Oelerich et al.· bioRxiv· 0 citations
A novel eight-gene signature associated with ischemic stroke is identified and resveratrol effectively modulates these genes through coordinated regulation of neuroinflammation, mitochondrial function, apoptosis, and metabolic pathways, and the multi-target therapeutic profile of resveratrol positions it as a promising...
S. Nirala, Sandeep Kumar Shah· Frontiers in Pharmacology· 0 citations
ABSTRACT DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engineering of DNA nanostructures. Using a nan...
Fan Yang, Minchao Liu, Qianqian Lu et al.· Angewandte Chemie· 0 citations
DNA nanostructures are programmable, biocompatible platforms for biomedicine; however, their mechanical properties are coupled to sequence and structural dimensions, limiting control over stiffness. Here, we report a paradigm shift from static design to mechanical engineering of DNA nanostructures. Using a nanoemulsion...
Fan Yang, Min-Chao Liu, Qian-Qian Lu et al.· Angewandte Chemie· 0 citations
Fig. 1: Integrated valorization pathway for sustainable food processing, illustrating the conversion of agro-waste and seaweeds into high-value proteins, starch, dietary fibres, bioactive compounds, and functional polysaccharides through green extraction technologies, followed by their application in active and intelli...
This work establishes spatial conformation as a programmable parameter for regulating nanoparticle biodistribution and clearance, thereby shifting the design paradigm from compositional adjustment to architectural control and opening avenues for targeted delivery, imaging, and immunotherapy.
Qian Chen, Fei Ding, Shuang-Ye Zhang et al.· ACS Applied Materials and In...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
