iNPH was associated with a broad and comparatively consistent CSF-centered metabolic phenotype, whereas plasma showed a smaller, partial and model-sensitive reflection of these alterations, which support altered energy substrate handling, redox and sulfur-associated metabolism, tryptophan-kynurenine metabolism and neur...
D. Visentin, D. Vukas, Z. Kolić et al.· medRxiv· 0 citations
Microalgae are a source of valuable compounds with broad applications in cosmeceuticals, nutraceuticals, renewable energy, and bioremediation. The present study employs the freshwater microalgae Tetradesmus dimorphus NUAC202 to investigate the effects of different microalgal growth media, like BG-11, Bold’s basal mediu...
P. Pongpadung, Nittaya Saninsi, Sunanthakan Khumman et al.· Journal of Phytology· 0 citations
Abstract Nattokinase (NK) is an orally administered subtilisin-family serine protease with reported activity across multiple interconnected proteolytic and cardiovascular targets, including degradation of SARS-CoV-2 spike protein, fibrinaloid amyloid microclots, fibrin clots, and classical amyloid substrates; enhanceme...
Nicolas Hulscher, Harvey A. Risch, James A. Thorp et al.· Zenodo (CERN European Organi...· 0 citations
Background Coronavirus disease 2019 (COVID-19) is frequently accompanied by extrapulmonary manifestations, including abnormal liver biochemistry. Although inflammatory markers are widely used in clinical assessment, their associations with hepatic biochemical abnormalities in hospitalized patients with COVID-19 remain...
Omar Alomair· Frontiers in Public Health· 0 citations
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The cardiovascular effects of smoking are generally evaluated in the context of acute ischemic injury. The possible association of smoking with subclinical cardiac autoimmunity and oxidative/inflammatory processes has been examined in relatively few studies. In this cross-sectional pilot study, we compared levels of ca...
Cronkhite-Canada syndrome (CCS) is an extremely rare non-hereditary syndrome (approximately 500 cases reported worldwide), characterized by diffuse gastrointestinal polyposis, ectodermal changes (alopecia, skin hyperpigmentation, onychodystrophy), and protein-losing enteropathy. Patients with CCS have a significantly i...
Min Li, Lun Li, Tao Wang· BMC Gastroenterology· 0 citations
High-spatial-resolution in situ mapping of biomolecules within tissue reveals critical insights into the complex molecular landscape and spatial organization of biological systems. Mass spectrometry imaging (MSI) is a powerful tool for spatially resolved molecular analysis of biological samples, with ongoing demand for...
Hua Zhang, Lang Ding, Thao U. Duong et al.· Nature Protocols· 0 citations
Background/Objective: Metabolic dysfunction-associated steatohepatitis (MASH), an advanced stage of metabolic dysfunction-associated steatotic liver disease (MASLD), is characterized by progressive liver fibrosis and represents an important therapeutic target. NP-011 is a truncated recombinant human milk fat globule EG...
Hyunjung Lee, Q. Tran, Tham Thi Bui et al.· Pharmaceutics· 0 citations
The spliceosome became very complex in eukaryogenesis. The Group IIA intron progenitor was associated with a single protein, homologous to spliceosomal Prp8, but the LECA spliceosome included ~140 proteins. The acquisition of proteins was a neutral process, providing a pool of factors for the development of a coordinat...
Olga V. Artemyeva-Isman· Preprints.org· 0 citations
Background Schizophrenia (SCZ) is a highly heterogeneous psychiatric disorder in which rare missense variants are increasingly recognized as major contributors to disease risk. Recent advances in next-generation sequencing (NGS), AlphaFold-based protein structure prediction, and machine learning provide unprecedented o...
Shaolei Teng, Malcolm Anthony, Qiaobin Yao et al.· European Neuropsychopharmaco...· 0 citations
PAIRWISE: Deep Learning-based Prediction of Effective Personalized Drug Combinations in CancerPAIRWISE predicts whether a drug pair acts synergistically in a specific tumour sample. It fuses three modalities — molecular graphs of the two compounds, theirdrug–target interaction profiles propagated over a protein–protein...
A) Western blot shows FGFR1 protein levels in WT-MCF7 and TR-MCF7 cells. GAPDH was as loading control. B) Relative expression of FGFR1 in WT-MCF7 and TR-MCF7 cells, measured by RT–qPCR and normalized to ACTB and RPLP1. Fold change was calculated relative to the geometric mean of ΔCq of the MCF7-WT condition. C) Western...
Torbjørn Amundsen. Lien, Sushil Dhakal, Anne Marthe. Fosdahl Wium et al.· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
