protein folding

Discovery of H-10 as a potent and safe GABAA receptor positive allosteric modulator: A novel benzothiazine-triazole lead compound with broad-spectrum anticonvulsant activity.

H-10 elicited dose-dependent seizure suppression and alleviated multi-organ pathological damage in both acute and chronic epileptic mouse models and is an orally bioavailable, efficacious GABAAR-targeted PAM with broad-spectrum antiseizure activity, deserving further optimization for anticonvulsant drug discovery.

ESMCHalo: halophile-associated protein prediction with frozen protein representations

ESMCHalo is a frozen protein-sequence predictor that combines ESMC-600M layer-36 canonical mean representations with five compact student heads trained using out-of-fold teacher targets with documented cross-fold limitations. The release provides frozen inference code, model checkpoints, calibration, a fixed threshold,...

Particle geometry governs protein corona-mediated neutrophil hitchhiking for enhanced tumor delivery

Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...

Particle geometry governs protein corona-mediated neutrophil hitchhiking for enhanced tumor delivery

Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...

Tardigrades have a complete condensin II: two divergent CAP-H2 kleisins in three eutardigrade genomes

Condensin II shapes interphase genome architecture: species that lack it tend to fold their chromosomes in a Rabl-like, type-I configuration, while species that have it form chromosome territories (type II). In the study that established this, the tardigrade Hypsibius dujardini (now H. exemplaris) was the only species...

A Streamlined One-Pot Extraction Method Enables High-Sensitivity Top-Down Proteomic Characterization of Phospholamban from Biopsy-Scale Cardiac Tissue

A streamlined Azo-enabled one-pot extraction strategy for high-sensitivity top-down analysis of PLN that reduces the required tissue input to 1 mg while preserving analytical performance and establishing a practical strategy for TDP of PLN proteoforms from biopsy-scale and other sample-limited myocardial specimens.

Particle geometry governs protein corona-mediated neutrophil hitchhiking for enhanced tumor delivery

Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...

The KH-like CTD of Prp5 is conserved and essential for splicing

Pre-mRNA splicing is a fundamental process in eukaryotic gene expression. The RNA helicase Prp5 bridges U1 and U2 snRNPs during spliceosome assembly and enhances splicing fidelity. While the N-terminal domain (NTD) of Prp5 is well characterized, the C-terminal domain (CTD) remains underexplored. Here, we show that CTD...

Particle geometry governs protein corona-mediated neutrophil hitchhiking for enhanced tumor delivery

Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...

esm2-layer-invariance: conditional layer invariance in protein language models (BIOINF-2026-2348 revision)

Complete analysis pipeline and per-dataset results for the revised version of BIOINF-2026-2348. Includes: (1) unified per-layer probing of ESM-2 650M and SaProt_650M_AF2 on all 63 ProteinGym substitution datasets under three feature arms (masked wild-type, unmasked wild-type, mutant) and four train-test splits (random,...

Strength training intervention with creatine/whey protein supplementation vs placebo on frailty in older adults with cirrhosis (STRIVE): A Randomized Controlled Trial

Particle geometry governs protein corona-mediated neutrophil hitchhiking for enhanced tumor delivery

Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...