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2,530 papers
Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...
Condensin II shapes interphase genome architecture: species that lack it tend to fold their chromosomes in a Rabl-like, type-I configuration, while species that have it form chromosome territories (type II). In the study that established this, the tardigrade Hypsibius dujardini (now H. exemplaris) was the only species...
Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...
Complete analysis pipeline and per-dataset results for the revised version of BIOINF-2026-2348. Includes: (1) unified per-layer probing of ESM-2 650M and SaProt_650M_AF2 on all 63 ProteinGym substitution datasets under three feature arms (masked wild-type, unmasked wild-type, mutant) and four train-test splits (random,...
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Complete analysis pipeline and per-dataset results for the revised version of BIOINF-2026-2348. Includes: (1) unified per-layer probing of ESM-2 650M and SaProt_650M_AF2 on all 63 ProteinGym substitution datasets under three feature arms (masked wild-type, unmasked wild-type, mutant) and four train-test splits (random,...
Marfan syndrome (MFS) is an autosomal dominant connective tissue disease caused by variants in the fibrillin 1 ( FBN1 ) gene. While common in humans, spontaneous animal models are rarely reported. We present the first phenotypic and molecular characterization of MFS in domestic cats. A pair of random-bred littermates e...
Condensin II shapes interphase genome architecture: species that lack it tend to fold their chromosomes in a Rabl-like, type-I configuration, while species that have it form chromosome territories (type II). In the study that established this, the tardigrade Hypsibius dujardini (now H. exemplaris) was the only species...
Versioned research release of the BBB permeability prediction project. This release preserves the complete source code, experimental results, documentation, figures, and reproducibility materials for the project. Contents: Phase 3: 5-fold scaffold CV classical ML (RF AUROC 0.921+/-0.024) Phase 4: Chemprop GNN ensemble...
Versioned research release of the BBB permeability prediction project. This release preserves the complete source code, experimental results, documentation, figures, and reproducibility materials for the project. Contents: Phase 3: 5-fold scaffold CV classical ML (RF AUROC 0.921+/-0.024) Phase 4: Chemprop GNN ensemble...
The integration of artificial intelligence (AI) in plant system biology enables the understanding of plant organization, revealing complex relations at the biological level. Plant systems biology aims at resolving the complex networks that define growth, development, stress responses, and metabolism by reframing inform...
The bioactivity of plant proteins is often limited by the compact and aggregated structures. In this study, the walnut protein-whey protein isolate (WP-WPIp) complex was constructed via pH cycling. This treatment appeared to induce conformational changes characterized by a disordering of secondary structures and a disr...
In this proposed model, anagrelide remodels the interactome of the PDE3A-SLFN12 complex, which relocalizes and accumulates near the mRNA entry channel of the 43S pre-initiation complex, which provides important mechanistic context for how PDE3A modulators act within the cell.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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