protein folding

Unraveling protein folding and structural dynamics

Domain classification of archaeal proteomes reveals conserved fold repertoire

Archaea represent one of the three domains of cellular life and yet account for fewer than 1% of experimentally determined protein structures, leaving the extent of their structural novelty unknown. Here we present a systematic domain-level classification of 124,075 proteins from 65 archaeal classes spanning 21 phyla a...

Deep learning for protein folding

Reduction in land area devoted to agriculture from a hypothetical universal vegan diet in Canada

This paper estimates the savings in agricultural land area that would occur in Canada if all domestically-produced and consumed animal food products (AFPs) and fish were replaced with domestically-produced high-protein plant food products (PFPs), accompanied by increases in consumption of domestically-produced fruits a...

Reveal the diagnostic value of a neutrophil inflammation- and cell death-associated gene signature in rheumatoid arthritis

This study aimed to construct an artificial neural network (ANN) diagnostic model for rheumatoid arthritis (RA) based on a neutrophil inflammation- and cell death-associated gene signature derived from a previously reported neutrophil extracellular traps (NETs)-related gene set, and to explore its association with immu...

Second-Generation AOH1996 Analogues with Enhanced Pharmacological Properties for Targeting PCNA

Second-generation AOH analogues with enhanced pharmacological properties were created through scaffold optimization, and both compounds induced robust G2/M arrest at lower concentrations than the parent molecule and significantly enhanced transcription–replication conflicts in pancreatic cancer cells.

The CCT6A paradigm: biomarker potential and therapeutic challenges in oncology and beyond

This review delineates CCT6A’s multifunctional roles in oncogenesis and immune-metabolic dysregulation, critically evaluates its biomarker potential, and proposes targeted therapeutic frameworks to refine precision medicine paradigms across diverse disease landscapes.

Advances in PMP22 sequence variant-associated hereditary neuropathy with liability to pressure palsies: from gene dosage effects to mechanism-informed variant interpretation

Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant neuropathy classically caused by a heterozygous deletion of the 17p11.2-p12 region encompassing PMP22. However, PMP22 sequence variants can produce HNPP-like or overlapping phenotypes, complicating variant interpretation. This narr...

Quantification of Folded Protein in Infant Formula and Through Processing Steps

Bioinformatics tools for protein modeling in cancer

Bioinformatics tools for protein modeling in neurodegenerative diseases

The credentials for Ribonuclease A to be catalytically active: The prerequisite of oxidative protein folding