protein folding

Insights Into Patient Variability During Ivacaftor-Lumacaftor Therapy in Cystic Fibrosis

Background: The advent of cystic fibrosis transmembrane conductance regulator protein (CFTR) modulators like ivacaftor have revolutionised the treatment of cystic fibrosis (CF). However, due to the plethora of variances in disease manifestations in CF, there are inherent challenges in unified responses under CFTR modul...

Carboxysome-Inspired Protein Coacervates for Light-Driven CO2 Reduction and H2 Evolution

Efficient catalysis often requires high local concentrations of reactants and catalysts, which cells achieve through compartmentalization within organelles, such as carboxysomes, that increase the efficiency of bacterial carbon fixation. Here, we engineered a photocatalytic reaction compartment that concentrated an art...

Programming Rubber-like Mechanics through Protein Folding

This repository contains the structural datasets and energetic analysis results used to guide the screening and evaluation of protein scaffolds for protein rubber. The workflow consists of two main stages: 1. A broad structural screening of 10,000 protein structural records from the PDB-derived CullPDB dataset, encompa...

Dextrocetirizine: The Neglected Enantiomer of Cetirizine - A Comprehensive Review on Its Pharmacological and Environmental Profile

The development of second-generation antihistamines represents a significant milestone in allergy management, driven by a continuous effort to optimize efficacy while minimizing sedating side effects. Central to this evolution is cetirizine, which was traditionally administered as a 50:50 racemic mixture. While the the...

From the Sultans of Reverse Swing to the Sultan of the Entire Universe: The Complete Unified N-K Model of Asymmetry and Divine Resonance — How the Navier–Stokes Solution Was Discovered from Cricket in 2025

N-K SCIENCES INTERNATIONAL PUBLICATION ZENODO SUBMISSION — DOI: 10.5281/zenodo.22759791 --- COMPLETE METADATA & DESCRIPTION Basic Information Field ValueTitle From the Sultans of Reverse Swing to the Sultan of the Entire Universe: The Complete Unified N-K Model of Asymmetry and Divine Resonance — How the Navier–Stokes...

Outer membrane proteins mediate unconventional secretion of Pseudomonas peroxidase through crosstalk between the Sec pathway and outer membrane vesicles

This study reveals the crosstalk between the Sec pathway and OMVs in the secretion of a non-canonical peroxidase, in which OM proteins, acting as the molecular tethers, mediate the stepwise secretion process and expands the understanding of non-classical protein secretion mechanisms and bacterial survival strategies.

Piercing mechanism in the minimal contractile tail of bacteriophage P2

A previously undescribed fold is identified in the head-to-tail adaptor, which mediates the transition from 12-fold portal symmetry to sixfold tail symmetry through interlocking β-strand “handshake” interactions and support a distinct model of contractile tail activation and expand the known architectural diversity of...

Cross-kingdom RNA interference in the dysbiosis-mediated network of vocal fold fibrosis: a pathogenic hypothesis and molecular intervention targets

Vocal fold fibrosis is the principal pathological basis of intractable voice disorders. Previous etiological models have attributed vocal fold scarring solely to mechanical trauma and chemical irritation, whereas the local mucosal microbiota of the vocal folds and its cross-kingdom regulation of host gene expression ha...

Sequential exposure to histological chorioamnionitis and postnatal hyperoxia alters gene expression in cord blood monocytes

Background Sequential exposure to heterologous noxious stimuli such as histological chorioamnionitis (HCA) and hyperoxia may elicit variable immune responses, resulting in distinct disease manifestations in the neonate. However, the molecular mechanisms underlying innate immune dysregulation in these contexts remain po...

Intermediate-Resolution Modeling of Dynamic DNAs and Their Phase Separation

An intermediate-resolution model for condensates of DNAs (iConDNA) that can capture key local and long-range structural features of dynamic DNAs and simulate their spontaneous phase transitions is introduced, providing a suitable tool to study DNA homotypic phase separation in biological and engineering applications.

Structural confidence and template coverage of selected proteins from Flavobacterium azizsancarii

Multidimensional neuropsychological heterogeneity in obstructive sleep apnea: deep clinical phenotyping in a single-center cohort, population proteomic context, and depressive-burden risk stratification

The findings support a multidimensional framework integrating differentiated clinical associations, a non-random general-population proteomic context, human functional transcriptomic context, and encouraging cross-setting depressive-burden risk ranking, while absolute probabilities remained less stable; OSA-specific mo...